Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3763674..3764224 Replicon chromosome
Accession NZ_CP091839
Organism Escherichia coli strain SWYHX138.261ft

Toxin (Protein)


Gene name ccdB Uniprot ID D3H432
Locus tag L7H22_RS18115 Protein ID WP_001160975.1
Coordinates 3763910..3764224 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag L7H22_RS18110 Protein ID WP_000125566.1
Coordinates 3763674..3763907 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7H22_RS18085 (3758745) 3758745..3759032 + 288 WP_000203741.1 ferredoxin-like protein FixX -
L7H22_RS18090 (3759090) 3759090..3760421 + 1332 WP_238059043.1 MFS transporter -
L7H22_RS18095 (3760532) 3760532..3761062 + 531 WP_097754168.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
L7H22_RS18100 (3761055) 3761055..3762917 + 1863 Protein_3527 glutathione-regulated potassium-efflux system protein KefC -
L7H22_RS18105 (3763109) 3763109..3763588 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
L7H22_RS18110 (3763674) 3763674..3763907 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
L7H22_RS18115 (3763910) 3763910..3764224 + 315 WP_001160975.1 CcdB family protein Toxin
L7H22_RS18120 (3764221) 3764221..3765069 - 849 WP_000257188.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
L7H22_RS18125 (3765076) 3765076..3765453 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
L7H22_RS18130 (3765456) 3765456..3766277 - 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
L7H22_RS18135 (3766274) 3766274..3767263 - 990 WP_072647158.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
L7H22_RS18140 (3767263) 3767263..3768549 - 1287 WP_171461421.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.76 Da        Isoelectric Point: 9.8517

>T234873 WP_001160975.1 NZ_CP091839:3763910-3764224 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T234873 NZ_LR134093:c2531976-2531869 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT234873 WP_000125566.1 NZ_CP091839:3763674-3763907 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT234873 NZ_LR134093:2531792-2531852 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References