Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3549350..3549945 Replicon chromosome
Accession NZ_CP091839
Organism Escherichia coli strain SWYHX138.261ft

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag L7H22_RS17080 Protein ID WP_000239577.1
Coordinates 3549595..3549945 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag L7H22_RS17075 Protein ID WP_001223208.1
Coordinates 3549350..3549601 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7H22_RS17065 (3545015) 3545015..3548794 + 3780 WP_238059014.1 autotransporter assembly complex protein TamB -
L7H22_RS17070 (3548797) 3548797..3549138 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
L7H22_RS17075 (3549350) 3549350..3549601 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
L7H22_RS17080 (3549595) 3549595..3549945 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
L7H22_RS17085 (3550022) 3550022..3550552 - 531 WP_000055075.1 inorganic diphosphatase -
L7H22_RS17090 (3550862) 3550862..3551818 + 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
L7H22_RS17095 (3551958) 3551958..3553460 + 1503 WP_000205807.1 sugar ABC transporter ATP-binding protein -
L7H22_RS17100 (3553474) 3553474..3554496 + 1023 WP_238059015.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T234872 WP_000239577.1 NZ_CP091839:3549595-3549945 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T234872 NZ_LR134093:c2506756-2506490 [Staphylococcus aureus]
ATGGTTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTAATTAAAAGTATTGACAGAAATGGTGCGTTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT234872 WP_001223208.1 NZ_CP091839:3549350-3549601 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT234872 NZ_LR134093:c2507007-2506756 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATAGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTGTAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References