Detailed information of TA system TA234830

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 154790..155361
• Replicon: plasmid unnamed
• Accession: NZ_CP091834
• Organism: Shewanella xiamenensis strain HD6452

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E846
• Locus tag: K5M76_RS22445
• Protein ID: WP_011074407.1
• Coordinates: 154790..155101 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: K5M76_RS22450
• Protein ID: WP_226060621.1
• Coordinates: 155101..155361 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5M76_RS22420 (K5M76_22385)	149968..150318	-	351	WP_195742682.1	hypothetical protein	-
K5M76_RS22425 (K5M76_22390)	150624..150836	-	213	Protein_174	antirestriction protein ArdR	-
K5M76_RS22430 (K5M76_22395)	150883..151053	-	171	WP_219640046.1	hypothetical protein	-
K5M76_RS22435 (K5M76_22400)	151085..151420	-	336	WP_014611690.1	hypothetical protein	-
K5M76_RS22440 (K5M76_22405)	151680..154766	-	3087	WP_259476901.1	Tn3 family transposase	-
K5M76_RS22445 (K5M76_22410)	154790..155101	-	312	WP_011074407.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K5M76_RS22450 (K5M76_22415)	155101..155361	-	261	WP_226060621.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K5M76_RS22455 (K5M76_22420)	155531..156112	+	582	WP_226060623.1	recombinase family protein	-
K5M76_RS22460 (K5M76_22425)	156294..156656	+	363	WP_226060624.1	winged helix-turn-helix domain-containing protein	-
K5M76_RS22465 (K5M76_22430)	156762..157532	+	771	WP_226060626.1	molybdate ABC transporter substrate-binding protein	-
K5M76_RS22470 (K5M76_22435)	157538..158248	+	711	WP_259476905.1	sulfite exporter TauE/SafE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	ARR-3 / dfrA27 / aadA16 / qacE / sul1 / blaNDM-1 / qnrVC6 / blaCMY-10 / mph(A) / blaTEM-1B / aac(3)-IId / msr(E) / mph(E) / tet(C) / aadA6	-	1..256918	256918
	-	flank	IS/Tn	-	-	158278..161295	3017

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-61)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11796.59 Da
• Isoelectric Point: 8.5262

>T234830 WP_011074407.1 NZ_CP091834:c155101-154790 [Shewanella xiamenensis]
MAVTYHLTPDAQSDLIGIHRFTLAQWGATQSKTYLSGLKQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLTHLAERETI

Nucleotide

• Length: 312 bp

>T234830 NZ_LR134091:c2079895-2079533 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9372.67 Da
• Isoelectric Point: 4.9373

>AT234830 WP_226060621.1 NZ_CP091834:c155361-155101 [Shewanella xiamenensis]
MNTLSANEAKIHFGDLLLKAQQSPIQINKNGKPVAVVISADEYQSIEALKLHLLQSKAVKAMSDIQTGNLIDGNTFFDEL
VAGQYD

Nucleotide

• Length: 261 bp

>AT234830 NZ_LR134091:c2080062-2079892 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Toxin

• AlphaFold DB: Q8E846