23483

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1812602..1814151 Replicon chromosome
Accession NC_011852
Organism Haemophilus parasuis SH0165

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HAPS_RS08985 Protein ID WP_015939932.1
Coordinates 1812835..1814151 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID U4SAZ6
Locus tag HAPS_RS08980 Protein ID WP_010786623.1
Coordinates 1812602..1812841 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAPS_RS08965 1808769..1809865 + 1097 Protein_1780 ISAs1 family transposase -
HAPS_RS08970 1810052..1811497 - 1446 WP_015939942.1 metalloprotease TldD -
HAPS_RS08975 1811628..1812455 + 828 WP_015939931.1 alpha/beta hydrolase -
HAPS_RS08980 1812602..1812841 + 240 WP_010786623.1 helix-turn-helix domain-containing protein Antitoxin
HAPS_RS08985 1812835..1814151 + 1317 WP_015939932.1 type II toxin-antitoxin system HipA family toxin Toxin
HAPS_RS12135 1814155..1814544 - 390 WP_202795088.1 hypothetical protein -
HAPS_RS12140 1814544..1815590 - 1047 WP_202795090.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
HAPS_RS08995 1815614..1816129 - 516 WP_080513259.1 hypothetical protein -
HAPS_RS09000 1816029..1816388 + 360 WP_010787368.1 hypothetical protein -
HAPS_RS09005 1816575..1817148 + 574 Protein_1789 virulence RhuM family protein -
HAPS_RS11715 1817229..1817345 - 117 Protein_1790 LysR family transcriptional regulator -
HAPS_RS09010 1817480..1817923 + 444 WP_015939865.1 nuclear transport factor 2 family protein -
HAPS_RS09015 1817923..1818102 + 180 Protein_1792 disulfide bond formation protein DsbA -
HAPS_RS09020 1818358..1818945 - 588 WP_015939943.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 50014.26 Da        Isoelectric Point: 7.6047

>T23483 WP_015939932.1 NC_011852:1812835-1814151 [Glaesserella parasuis SH0165]
MVMRLRVLMNGEMVGYFDRTLSGSHHFTYAESWLNSPLARPISLSMPLQRATYQGKEVINFFDNLLPDNPQIRARIATRF
NAETQQPFDLLAKIGRDAAGAITLLGEDEQIPNHRIIQATELNESEMTKILQSYQYNAPLGMIDNNQDFRISIAGAQEKT
ALLWHNGKWKLPHGLTPTTHIFKLPMGEIRTPKHLLDLSKSVDNELVCLRLFSAFNIPSANVELLEMNDIRALAVERFDR
RLSQDGSYFLRLPYEDFCQAFGLSPTQKYESDGGIGIGDMMNKLLYSSNSNDRRQFMQTQFLFWLLAAIDGHAKNFSLAI
EKQGRYHLSPVYDVISAYPMLGGKGWHHSELQMAMSLRSTQKGKKWHWNKIYAEHFYATAKFVGFSSSDMKQVIEQICDT
VQETIDSVATTLPKQIDENVRDQIFTGIMKQVQKVSMK

Download         Length: 1317 bp

>T23483 NC_011852:1812835-1814151 [Glaesserella parasuis SH0165]
ATGGTAATGCGATTACGAGTATTAATGAATGGCGAAATGGTTGGGTATTTTGACCGCACTTTATCGGGTTCCCACCATTT
TACCTATGCTGAAAGTTGGCTAAATTCCCCATTAGCTCGCCCGATTTCCCTTTCTATGCCCTTGCAAAGAGCAACATATC
AAGGCAAAGAAGTGATTAATTTCTTTGATAATTTACTGCCCGATAATCCTCAAATTCGAGCAAGAATTGCGACAAGATTT
AATGCTGAAACACAACAACCTTTTGACTTACTTGCTAAAATTGGTCGCGATGCTGCGGGTGCTATTACTCTTTTAGGGGA
AGATGAACAAATTCCTAATCATCGAATAATTCAAGCCACAGAATTAAACGAGAGTGAAATGACGAAAATTCTACAAAGTT
ATCAATACAATGCCCCACTTGGTATGATTGATAATAATCAGGACTTCAGAATTTCTATTGCTGGTGCACAAGAAAAGACA
GCTCTGCTTTGGCATAACGGCAAATGGAAATTACCACACGGATTGACCCCGACAACGCATATTTTCAAATTGCCTATGGG
AGAAATTCGTACCCCTAAACACCTGCTTGATCTGTCAAAAAGTGTAGATAACGAACTCGTCTGTTTGAGATTATTTTCTG
CTTTCAATATCCCTTCCGCAAACGTTGAATTATTGGAAATGAACGATATACGGGCATTAGCTGTTGAACGTTTTGATCGC
CGTCTTAGTCAAGATGGCAGTTATTTTTTACGTTTACCTTACGAAGATTTCTGTCAGGCATTCGGCTTATCGCCAACGCA
AAAATATGAAAGCGATGGTGGAATTGGTATTGGGGATATGATGAATAAGTTGCTCTACTCCAGTAATTCCAACGATCGCC
GTCAATTTATGCAAACTCAATTTCTGTTTTGGCTACTGGCAGCCATTGATGGACACGCTAAAAACTTTTCTCTCGCCATT
GAAAAACAAGGGCGTTATCACTTATCCCCAGTGTATGACGTAATTTCTGCTTATCCAATGTTAGGCGGAAAAGGTTGGCA
TCACAGTGAATTACAAATGGCAATGAGCTTGCGTAGTACACAAAAAGGGAAAAAATGGCATTGGAATAAAATTTACGCTG
AACATTTCTATGCCACAGCTAAGTTTGTCGGATTTAGCTCAAGTGATATGAAACAAGTGATAGAGCAAATTTGCGATACA
GTGCAAGAAACCATTGATAGCGTAGCAACAACACTACCCAAACAGATAGATGAAAATGTACGGGATCAAATATTCACGGG
CATAATGAAACAGGTGCAAAAAGTTTCTATGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9059.47 Da        Isoelectric Point: 9.7684

>AT23483 WP_010786623.1 NC_011852:1812602-1812841 [Glaesserella parasuis SH0165]
MLITTPDMLGNSLRDIRKQKKLSQMQIANQVALRQATISTFEKKTDKATIETLFKLLSGLGYELHIQPRPEKTEGNDEW

Download         Length: 240 bp

>AT23483 NC_011852:1812602-1812841 [Glaesserella parasuis SH0165]
ATGTTAATCACGACACCAGATATGCTTGGAAATAGCCTACGCGATATTCGTAAGCAAAAAAAGCTTTCTCAAATGCAAAT
AGCAAATCAAGTAGCTTTAAGACAAGCCACGATTTCCACCTTTGAGAAAAAAACCGATAAAGCCACTATTGAAACATTAT
TCAAGTTACTTTCAGGTTTAGGCTATGAACTACATATCCAACCTCGTCCTGAAAAAACAGAGGGGAATGATGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U4SAZ6

References