Detailed information of TA system TA023483

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1812602..1814151
• Replicon: chromosome
• Accession: NC_011852
• Organism: Haemophilus parasuis SH0165

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HAPS_RS08985
• Protein ID: WP_015939932.1
• Coordinates: 1812835..1814151 (+)
• Length: 439 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: U4SAZ6
• Locus tag: HAPS_RS08980
• Protein ID: WP_010786623.1
• Coordinates: 1812602..1812841 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAPS_RS08965	1808769..1809865	+	1097	Protein_1780	ISAs1 family transposase	-
HAPS_RS08970	1810052..1811497	-	1446	WP_015939942.1	metalloprotease TldD	-
HAPS_RS08975	1811628..1812455	+	828	WP_015939931.1	alpha/beta hydrolase	-
HAPS_RS08980	1812602..1812841	+	240	WP_010786623.1	helix-turn-helix domain-containing protein	Antitoxin
HAPS_RS08985	1812835..1814151	+	1317	WP_015939932.1	type II toxin-antitoxin system HipA family toxin	Toxin
HAPS_RS12135	1814155..1814544	-	390	WP_202795088.1	hypothetical protein	-
HAPS_RS12140	1814544..1815590	-	1047	WP_202795090.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
HAPS_RS08995	1815614..1816129	-	516	WP_080513259.1	hypothetical protein	-
HAPS_RS09000	1816029..1816388	+	360	WP_010787368.1	hypothetical protein	-
HAPS_RS09005	1816575..1817148	+	574	Protein_1789	virulence RhuM family protein	-
HAPS_RS11715	1817229..1817345	-	117	Protein_1790	LysR family transcriptional regulator	-
HAPS_RS09010	1817480..1817923	+	444	WP_015939865.1	nuclear transport factor 2 family protein	-
HAPS_RS09015	1817923..1818102	+	180	Protein_1792	disulfide bond formation protein DsbA	-
HAPS_RS09020	1818358..1818945	-	588	WP_015939943.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-104)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-66)

Sequences

Toxin

Protein

• Length: 439 a.a.
• Molecular weight: 50014.26 Da
• Isoelectric Point: 7.6047

>T23483 WP_015939932.1 NC_011852:1812835-1814151 [Glaesserella parasuis SH0165]
MVMRLRVLMNGEMVGYFDRTLSGSHHFTYAESWLNSPLARPISLSMPLQRATYQGKEVINFFDNLLPDNPQIRARIATRF
NAETQQPFDLLAKIGRDAAGAITLLGEDEQIPNHRIIQATELNESEMTKILQSYQYNAPLGMIDNNQDFRISIAGAQEKT
ALLWHNGKWKLPHGLTPTTHIFKLPMGEIRTPKHLLDLSKSVDNELVCLRLFSAFNIPSANVELLEMNDIRALAVERFDR
RLSQDGSYFLRLPYEDFCQAFGLSPTQKYESDGGIGIGDMMNKLLYSSNSNDRRQFMQTQFLFWLLAAIDGHAKNFSLAI
EKQGRYHLSPVYDVISAYPMLGGKGWHHSELQMAMSLRSTQKGKKWHWNKIYAEHFYATAKFVGFSSSDMKQVIEQICDT
VQETIDSVATTLPKQIDENVRDQIFTGIMKQVQKVSMK

Nucleotide

• Length: 1317 bp

>T23483 NC_011852:1812835-1814151 [Glaesserella parasuis SH0165]
ATGGTAATGCGATTACGAGTATTAATGAATGGCGAAATGGTTGGGTATTTTGACCGCACTTTATCGGGTTCCCACCATTT
TACCTATGCTGAAAGTTGGCTAAATTCCCCATTAGCTCGCCCGATTTCCCTTTCTATGCCCTTGCAAAGAGCAACATATC
AAGGCAAAGAAGTGATTAATTTCTTTGATAATTTACTGCCCGATAATCCTCAAATTCGAGCAAGAATTGCGACAAGATTT
AATGCTGAAACACAACAACCTTTTGACTTACTTGCTAAAATTGGTCGCGATGCTGCGGGTGCTATTACTCTTTTAGGGGA
AGATGAACAAATTCCTAATCATCGAATAATTCAAGCCACAGAATTAAACGAGAGTGAAATGACGAAAATTCTACAAAGTT
ATCAATACAATGCCCCACTTGGTATGATTGATAATAATCAGGACTTCAGAATTTCTATTGCTGGTGCACAAGAAAAGACA
GCTCTGCTTTGGCATAACGGCAAATGGAAATTACCACACGGATTGACCCCGACAACGCATATTTTCAAATTGCCTATGGG
AGAAATTCGTACCCCTAAACACCTGCTTGATCTGTCAAAAAGTGTAGATAACGAACTCGTCTGTTTGAGATTATTTTCTG
CTTTCAATATCCCTTCCGCAAACGTTGAATTATTGGAAATGAACGATATACGGGCATTAGCTGTTGAACGTTTTGATCGC
CGTCTTAGTCAAGATGGCAGTTATTTTTTACGTTTACCTTACGAAGATTTCTGTCAGGCATTCGGCTTATCGCCAACGCA
AAAATATGAAAGCGATGGTGGAATTGGTATTGGGGATATGATGAATAAGTTGCTCTACTCCAGTAATTCCAACGATCGCC
GTCAATTTATGCAAACTCAATTTCTGTTTTGGCTACTGGCAGCCATTGATGGACACGCTAAAAACTTTTCTCTCGCCATT
GAAAAACAAGGGCGTTATCACTTATCCCCAGTGTATGACGTAATTTCTGCTTATCCAATGTTAGGCGGAAAAGGTTGGCA
TCACAGTGAATTACAAATGGCAATGAGCTTGCGTAGTACACAAAAAGGGAAAAAATGGCATTGGAATAAAATTTACGCTG
AACATTTCTATGCCACAGCTAAGTTTGTCGGATTTAGCTCAAGTGATATGAAACAAGTGATAGAGCAAATTTGCGATACA
GTGCAAGAAACCATTGATAGCGTAGCAACAACACTACCCAAACAGATAGATGAAAATGTACGGGATCAAATATTCACGGG
CATAATGAAACAGGTGCAAAAAGTTTCTATGAAGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9059.47 Da
• Isoelectric Point: 9.7684

>AT23483 WP_010786623.1 NC_011852:1812602-1812841 [Glaesserella parasuis SH0165]
MLITTPDMLGNSLRDIRKQKKLSQMQIANQVALRQATISTFEKKTDKATIETLFKLLSGLGYELHIQPRPEKTEGNDEW

Nucleotide

• Length: 240 bp

>AT23483 NC_011852:1812602-1812841 [Glaesserella parasuis SH0165]
ATGTTAATCACGACACCAGATATGCTTGGAAATAGCCTACGCGATATTCGTAAGCAAAAAAAGCTTTCTCAAATGCAAAT
AGCAAATCAAGTAGCTTTAAGACAAGCCACGATTTCCACCTTTGAGAAAAAAACCGATAAAGCCACTATTGAAACATTAT
TCAAGTTACTTTCAGGTTTAGGCTATGAACTACATATCCAACCTCGTCCTGAAAAAACAGAGGGGAATGATGAATGGTAA

Structures

Antitoxin

• AlphaFold DB: U4SAZ6