234829

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParE-CopA/ParE-RHH
Location 4406016..4406581 Replicon chromosome
Accession NZ_CP091833
Organism Shewanella xiamenensis strain HD6452

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag K5M76_RS19340 Protein ID WP_259475352.1
Coordinates 4406288..4406581 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name copA Uniprot ID A0A448EM94
Locus tag K5M76_RS19335 Protein ID WP_011716807.1
Coordinates 4406016..4406300 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5M76_RS19295 (K5M76_19260) 4401255..4401452 - 198 WP_011920077.1 AlpA family transcriptional regulator -
K5M76_RS19300 (K5M76_19265) 4401585..4402091 + 507 WP_259475342.1 DNA repair protein RadC -
K5M76_RS19305 (K5M76_19270) 4402139..4402501 + 363 WP_259475343.1 hypothetical protein -
K5M76_RS19310 (K5M76_19275) 4402629..4402985 + 357 WP_259475344.1 type IV toxin-antitoxin system YeeU family antitoxin -
K5M76_RS19315 (K5M76_19280) 4403232..4403645 + 414 WP_037422948.1 DUF2787 domain-containing protein -
K5M76_RS19320 (K5M76_19285) 4403836..4404243 + 408 WP_055648801.1 DUF2787 domain-containing protein -
K5M76_RS19325 (K5M76_19290) 4404352..4404918 + 567 WP_259475348.1 site-specific integrase -
K5M76_RS19330 (K5M76_19295) 4405007..4405729 + 723 WP_259475349.1 lecithin retinol acyltransferase family protein -
K5M76_RS19335 (K5M76_19300) 4406016..4406300 + 285 WP_011716807.1 CopG family ribbon-helix-helix protein Antitoxin
K5M76_RS19340 (K5M76_19305) 4406288..4406581 + 294 WP_259475352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5M76_RS19345 (K5M76_19310) 4406772..4407440 - 669 WP_259475354.1 inovirus Gp2 family protein -
K5M76_RS19350 (K5M76_19315) 4407750..4409063 - 1314 WP_259475356.1 helix-turn-helix domain-containing protein -
K5M76_RS19355 (K5M76_19320) 4409253..4410083 + 831 WP_037430221.1 hypothetical protein -
K5M76_RS19360 (K5M76_19325) 4410576..4411322 + 747 WP_099457349.1 iron-sulfur cluster repair di-iron protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-44)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11086.57 Da        Isoelectric Point: 5.1035

>T234829 WP_259475352.1 NZ_CP091833:4406288-4406581 [Shewanella xiamenensis]
MPQIVFTATALSDLERLREFLRSKNPPAAQRAASAIINTIRKLESYPDIGRPIDDNDFSFRELLIDFGDTGYLTMYQYDG
GERLTVLCIRHQKEAGY

Download         Length: 294 bp

>T234829 NZ_LR134091:c1980024-1979848 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10955.25 Da        Isoelectric Point: 5.9920

>AT234829 WP_011716807.1 NZ_CP091833:4406016-4406300 [Shewanella xiamenensis]
MSTIKPVSVKLDADIKARVEHLAETRKRSSHWMMREAIREYVEREEKREALQQEALRAWEEHQTSGLHVTGDEVVSWLES
WGSENEQAAPTCHK

Download         Length: 285 bp

>AT234829 NZ_LR134091:1979725-1979780 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A448EM94

References