Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 3342900..3343492 | Replicon | chromosome |
| Accession | NZ_CP091833 | ||
| Organism | Shewanella xiamenensis strain HD6452 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A252ENI2 |
| Locus tag | K5M76_RS14625 | Protein ID | WP_014610888.1 |
| Coordinates | 3342900..3343154 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A252ENK1 |
| Locus tag | K5M76_RS14630 | Protein ID | WP_014610929.1 |
| Coordinates | 3343151..3343492 (+) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K5M76_RS14595 (K5M76_14560) | 3338480..3339646 | + | 1167 | WP_115014222.1 | DUF3596 domain-containing protein | - |
| K5M76_RS14600 (K5M76_14565) | 3339720..3340406 | + | 687 | WP_139122580.1 | zeta toxin family protein | - |
| K5M76_RS14605 (K5M76_14570) | 3340466..3340630 | + | 165 | WP_014610884.1 | hypothetical protein | - |
| K5M76_RS14610 (K5M76_14575) | 3340708..3340884 | - | 177 | WP_197721152.1 | tyrosine-type recombinase/integrase | - |
| K5M76_RS14615 (K5M76_14580) | 3340956..3341508 | - | 553 | Protein_2836 | GDP-mannose 4,6-dehydratase | - |
| K5M76_RS14620 (K5M76_14585) | 3341539..3342688 | - | 1150 | Protein_2837 | IS3 family transposase | - |
| K5M76_RS14625 (K5M76_14590) | 3342900..3343154 | + | 255 | WP_014610888.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| K5M76_RS14630 (K5M76_14595) | 3343151..3343492 | + | 342 | WP_014610929.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| K5M76_RS14635 (K5M76_14600) | 3343656..3344036 | - | 381 | WP_086904820.1 | helix-turn-helix transcriptional regulator | - |
| K5M76_RS14640 (K5M76_14605) | 3344033..3345400 | - | 1368 | WP_259474949.1 | HipA domain-containing protein | - |
| K5M76_RS14645 (K5M76_14610) | 3345755..3346054 | - | 300 | Protein_2842 | CcdB family protein | - |
| K5M76_RS14650 (K5M76_14615) | 3346134..3346538 | - | 405 | WP_069453179.1 | IS200/IS605 family transposase | - |
| K5M76_RS14655 (K5M76_14620) | 3346585..3347679 | + | 1095 | WP_088585325.1 | RNA-guided endonuclease TnpB family protein | - |
| K5M76_RS14660 (K5M76_14625) | 3347698..3347943 | - | 246 | WP_014610893.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 3348021..3349634 | 1613 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9480.99 Da Isoelectric Point: 10.1453
>T234828 WP_014610888.1 NZ_CP091833:3342900-3343154 [Shewanella xiamenensis]
MNKKHLRTLTAIFARPVSGAIKWSDIEALFIALGADIEEREGSRIGVVLFGEVQVYHRPHPQKETDKDAVISIKKWLERN
GVKA
MNKKHLRTLTAIFARPVSGAIKWSDIEALFIALGADIEEREGSRIGVVLFGEVQVYHRPHPQKETDKDAVISIKKWLERN
GVKA
Download Length: 255 bp
>T234828 NZ_LR134091:c1877186-1877034 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12379.91 Da Isoelectric Point: 4.3992
>AT234828 WP_014610929.1 NZ_CP091833:3343151-3343492 [Shewanella xiamenensis]
MKNLMMINGVKAFIDYDPDAETFRGEFVGLNGGADFYGESVAQLEAEGAKSLSVFLEMCQERGIEPYKNFSGKFNVRISP
EVHARLNEIALSQSISLNAAVENAVNDYIAHSA
MKNLMMINGVKAFIDYDPDAETFRGEFVGLNGGADFYGESVAQLEAEGAKSLSVFLEMCQERGIEPYKNFSGKFNVRISP
EVHARLNEIALSQSISLNAAVENAVNDYIAHSA
Download Length: 342 bp
>AT234828 NZ_LR134091:c1877810-1877211 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGACACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGACACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A252ENI2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A252ENK1 |