Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | VII | Classification (family/domain) | HepT-MntA/HepT(toxin) |
Location | 3301394..3302210 | Replicon | chromosome |
Accession | NZ_CP091833 | ||
Organism | Shewanella xiamenensis strain HD6452 |
Toxin (Protein)
Gene name | hepT | Uniprot ID | A0A252EQR5 |
Locus tag | K5M76_RS14480 | Protein ID | WP_069455295.1 |
Coordinates | 3301809..3302210 (+) | Length | 134 a.a. |
Antitoxin (Protein)
Gene name | mntA | Uniprot ID | A0A501X4H4 |
Locus tag | K5M76_RS14475 | Protein ID | WP_069455294.1 |
Coordinates | 3301394..3301816 (+) | Length | 141 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K5M76_RS14450 (K5M76_14420) | 3296483..3297025 | - | 543 | WP_037428279.1 | dTDP-4-dehydrorhamnose 3,5-epimerase | - |
K5M76_RS14455 (K5M76_14425) | 3297012..3297902 | - | 891 | WP_259474938.1 | glucose-1-phosphate thymidylyltransferase RfbA | - |
K5M76_RS14460 (K5M76_14430) | 3298046..3299407 | - | 1362 | WP_259474939.1 | GAF domain-containing sensor histidine kinase | - |
K5M76_RS14465 (K5M76_14435) | 3299798..3300244 | + | 447 | WP_224022139.1 | copper resistance protein NlpE | - |
K5M76_RS14470 (K5M76_14440) | 3300520..3301287 | + | 768 | WP_259474940.1 | HutD family protein | - |
K5M76_RS14475 (K5M76_14445) | 3301394..3301816 | + | 423 | WP_069455294.1 | type II toxin-antitoxin system antitoxin | Antitoxin |
K5M76_RS14480 (K5M76_14450) | 3301809..3302210 | + | 402 | WP_069455295.1 | type II toxin-antitoxin system toxin | Toxin |
K5M76_RS14485 (K5M76_14455) | 3302404..3303435 | - | 1032 | WP_088585343.1 | dTDP-glucose 4,6-dehydratase | - |
K5M76_RS14490 (K5M76_14460) | 3303942..3304283 | - | 342 | Protein_2811 | transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 3304035..3304232 | 197 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 15296.57 Da Isoelectric Point: 6.3185
>T234827 WP_069455295.1 NZ_CP091833:3301809-3302210 [Shewanella xiamenensis]
MNDIIINKIATIKRCIKRIQQVYGDGSQFKQDFTLQDSVILNLQRCCEACIDIANHINRQQQLGIPQSSRDSFTLLAQNN
LITQPLADNLKKMVGLRNIAVHDYQELNLDIVVHVVQHHLEDFEQFIDVIKAE
MNDIIINKIATIKRCIKRIQQVYGDGSQFKQDFTLQDSVILNLQRCCEACIDIANHINRQQQLGIPQSSRDSFTLLAQNN
LITQPLADNLKKMVGLRNIAVHDYQELNLDIVVHVVQHHLEDFEQFIDVIKAE
Download Length: 402 bp
>T234827 NZ_LR134091:c831085-830897 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
Antitoxin
Download Length: 141 a.a. Molecular weight: 15795.88 Da Isoelectric Point: 5.1520
>AT234827 WP_069455294.1 NZ_CP091833:3301394-3301816 [Shewanella xiamenensis]
MQQLNEKKIIKLLRDNIPKLQLIYLFGSYSQGTQHRNSDIDIAVLAADTLDNIARWELAQKLASALDSDVDLVDLRSAST
VLCQQVVTQGKQLWGTQQDDELFAVKTISMYQHLQAERQAIIDDVMANTAAKDHRGSHFE
MQQLNEKKIIKLLRDNIPKLQLIYLFGSYSQGTQHRNSDIDIAVLAADTLDNIARWELAQKLASALDSDVDLVDLRSAST
VLCQQVVTQGKQLWGTQQDDELFAVKTISMYQHLQAERQAIIDDVMANTAAKDHRGSHFE
Download Length: 423 bp
>AT234827 NZ_LR134091:c831374-831114 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A252EQR5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A501X4H4 |