Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 3301394..3302210 Replicon chromosome
Accession NZ_CP091833
Organism Shewanella xiamenensis strain HD6452

Toxin (Protein)


Gene name hepT Uniprot ID A0A252EQR5
Locus tag K5M76_RS14480 Protein ID WP_069455295.1
Coordinates 3301809..3302210 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID A0A501X4H4
Locus tag K5M76_RS14475 Protein ID WP_069455294.1
Coordinates 3301394..3301816 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5M76_RS14450 (K5M76_14420) 3296483..3297025 - 543 WP_037428279.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
K5M76_RS14455 (K5M76_14425) 3297012..3297902 - 891 WP_259474938.1 glucose-1-phosphate thymidylyltransferase RfbA -
K5M76_RS14460 (K5M76_14430) 3298046..3299407 - 1362 WP_259474939.1 GAF domain-containing sensor histidine kinase -
K5M76_RS14465 (K5M76_14435) 3299798..3300244 + 447 WP_224022139.1 copper resistance protein NlpE -
K5M76_RS14470 (K5M76_14440) 3300520..3301287 + 768 WP_259474940.1 HutD family protein -
K5M76_RS14475 (K5M76_14445) 3301394..3301816 + 423 WP_069455294.1 type II toxin-antitoxin system antitoxin Antitoxin
K5M76_RS14480 (K5M76_14450) 3301809..3302210 + 402 WP_069455295.1 type II toxin-antitoxin system toxin Toxin
K5M76_RS14485 (K5M76_14455) 3302404..3303435 - 1032 WP_088585343.1 dTDP-glucose 4,6-dehydratase -
K5M76_RS14490 (K5M76_14460) 3303942..3304283 - 342 Protein_2811 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3304035..3304232 197


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(12-129)

Antitoxin

Polymerase beta, nucleotidyltransferase

(7-97)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15296.57 Da        Isoelectric Point: 6.3185

>T234827 WP_069455295.1 NZ_CP091833:3301809-3302210 [Shewanella xiamenensis]
MNDIIINKIATIKRCIKRIQQVYGDGSQFKQDFTLQDSVILNLQRCCEACIDIANHINRQQQLGIPQSSRDSFTLLAQNN
LITQPLADNLKKMVGLRNIAVHDYQELNLDIVVHVVQHHLEDFEQFIDVIKAE

Download         Length: 402 bp

>T234827 NZ_LR134091:c831085-830897 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15795.88 Da        Isoelectric Point: 5.1520

>AT234827 WP_069455294.1 NZ_CP091833:3301394-3301816 [Shewanella xiamenensis]
MQQLNEKKIIKLLRDNIPKLQLIYLFGSYSQGTQHRNSDIDIAVLAADTLDNIARWELAQKLASALDSDVDLVDLRSAST
VLCQQVVTQGKQLWGTQQDDELFAVKTISMYQHLQAERQAIIDDVMANTAAKDHRGSHFE

Download         Length: 423 bp

>AT234827 NZ_LR134091:c831374-831114 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A252EQR5

Antitoxin

Source ID Structure
AlphaFold DB A0A501X4H4

References