Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ygfYX/Cpta(toxin)
Location 1377218..1377887 Replicon chromosome
Accession NZ_CP091833
Organism Shewanella xiamenensis strain HD6452

Toxin (Protein)


Gene name ygfX Uniprot ID -
Locus tag K5M76_RS06010 Protein ID WP_037427583.1
Coordinates 1377447..1377887 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name ygfY Uniprot ID -
Locus tag K5M76_RS06005 Protein ID WP_086024007.1
Coordinates 1377218..1377466 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5M76_RS05980 (K5M76_05965) 1372854..1373660 + 807 WP_037415571.1 prolipoprotein diacylglyceryl transferase -
K5M76_RS05985 (K5M76_05970) 1373660..1374454 + 795 WP_037415574.1 thymidylate synthase -
K5M76_RS05990 (K5M76_05975) 1374572..1375741 + 1170 WP_037415576.1 Na+/H+ antiporter NhaA -
K5M76_RS05995 (K5M76_05980) 1375744..1376130 + 387 WP_037415577.1 hypothetical protein -
K5M76_RS06000 (K5M76_05985) 1376225..1377133 + 909 WP_037415659.1 transcriptional activator NhaR -
K5M76_RS06005 (K5M76_05990) 1377218..1377466 + 249 WP_086024007.1 succinate dehydrogenase assembly factor 2 Antitoxin
K5M76_RS06010 (K5M76_05995) 1377447..1377887 + 441 WP_037427583.1 hypothetical protein Toxin
K5M76_RS06015 (K5M76_06000) 1378003..1379616 - 1614 WP_037415581.1 L-aspartate oxidase -
K5M76_RS06020 (K5M76_06005) 1379806..1380384 + 579 WP_037415584.1 RNA polymerase sigma factor RpoE -
K5M76_RS06025 (K5M76_06010) 1380426..1381037 + 612 WP_037427581.1 RseA family anti-sigma factor -
K5M76_RS06030 (K5M76_06015) 1381050..1381982 + 933 WP_037427579.1 MucB/RseB C-terminal domain-containing protein -
K5M76_RS06035 (K5M76_06020) 1381994..1382467 + 474 WP_037427577.1 SoxR reducing system RseC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(5-134)

Antitoxin

Flavinator of succinate dehydrogenase

(7-77)


Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16965.80 Da        Isoelectric Point: 7.7355

>T234826 WP_037427583.1 NZ_CP091833:1377447-1377887 [Shewanella xiamenensis]
VAELRHSFSVKASFDQRLSLVVFVCVCSTSLLLWPETDTAVLHGLRAIFAVLILGFLCSQLWQLRKWHYRFELNGQGEGW
LSTGEAFHVLQRTWVTPFICLVYYQSADRLHLLPLWADMFSDTDYRHLCRLLLKVKTQAVSQHELL

Download         Length: 441 bp

>T234826 NZ_LR134090:c2567009-2566743 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTGATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9641.24 Da        Isoelectric Point: 4.3440

>AT234826 WP_086024007.1 NZ_CP091833:1377218-1377466 [Shewanella xiamenensis]
MELMNIARVRWACRRGMLELDVLFQPFVENVYQDLSDEDKALFIRLLECEDPELFAWFMGHEVCPDPELARMIVQVRGRA
AP

Download         Length: 249 bp

>AT234826 NZ_LR134090:c2567266-2567009 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References