Detailed information of TA system TA234825

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 702846..704387
• Replicon: chromosome
• Accession: NZ_CP091833
• Organism: Shewanella xiamenensis strain HD6452

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: K5M76_RS03070
• Protein ID: WP_224021108.1
• Coordinates: 703086..704387 (+)
• Length: 434 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: K5M76_RS03065
• Protein ID: WP_047539109.1
• Coordinates: 702846..703082 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5M76_RS03045 (K5M76_03030)	697852..698841	+	990	WP_109277898.1	LysR family transcriptional regulator	-
K5M76_RS03050 (K5M76_03035)	698838..700196	-	1359	WP_037414232.1	MATE family efflux transporter	-
K5M76_RS03055 (K5M76_03040)	700424..700714	+	291	WP_011071021.1	co-chaperone GroES	-
K5M76_RS03060 (K5M76_03045)	700773..702410	+	1638	WP_037430013.1	chaperonin GroEL	-
K5M76_RS03065 (K5M76_03050)	702846..703082	+	237	WP_047539109.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
K5M76_RS03070 (K5M76_03055)	703086..704387	+	1302	WP_224021108.1	type II toxin-antitoxin system toxin serine/threonine-protein kinase HipA	Toxin
K5M76_RS03075 (K5M76_03060)	704629..705732	+	1104	WP_169548580.1	AAA family ATPase	-
K5M76_RS03080 (K5M76_03065)	705693..706394	+	702	WP_224021107.1	DUF4276 family protein	-
K5M76_RS03085 (K5M76_03070)	706683..706985	+	303	WP_140907371.1	cytochrome C	-
K5M76_RS03090 (K5M76_03075)	706987..708213	+	1227	WP_224021106.1	sulfite oxidase	-
K5M76_RS03095 (K5M76_03080)	708213..708596	+	384	WP_259476106.1	cytochrome C	-
K5M76_RS03100 (K5M76_03085)	708593..708928	+	336	WP_224021105.1	c-type cytochrome	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (9-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-64)

Sequences

Toxin

Protein

• Length: 434 a.a.
• Molecular weight: 48784.16 Da
• Isoelectric Point: 5.4888

>T234825 WP_224021108.1 NZ_CP091833:703086-704387 [Shewanella xiamenensis]
MSTAKTLTLEMHLGDLMIGELSFDATTDTFAVYYTKDWQQSGFPLSPTIPLDCTGTSNQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAIAFVPKGALLPETQLRPIKAAEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GKEFAFAEGTLSSTHIVKFEKYHHLVINEFITMRLAKVIGMNVANVDIVHFGSYKALCVERFDRRYIPSEQRVLRRHIVD
SCQALGFSVSKKYERNFGTGRDVKDIREGVSFKRLFSLAEKCRNPVAAKQDILQWTLFNLLTGNADAHGKNYSFFMTPSG
MEPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIYAYQLAAFMDGLGLPRNLLVSNLTRIARRIPQAIAEVILMLPPLD
EDEASFVAHYKAQLLARCERYLSFADEVRDVEV

Nucleotide

• Length: 1302 bp

>T234825 NZ_LR134090:c2510176-2509910 [Staphylococcus aureus]
ATGGATAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGCAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATAAAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8500.83 Da
• Isoelectric Point: 7.9727

>AT234825 WP_047539109.1 NZ_CP091833:702846-703082 [Shewanella xiamenensis]
MASPLNQQSLGLLIKERRKSAALTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIDIVSAQTSNTETNGWY

Nucleotide

• Length: 237 bp

>AT234825 NZ_LR134090:c2510427-2510176 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA