Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4757929..4758445 Replicon chromosome
Accession NZ_CP091813
Organism Klebsiella pneumoniae strain 10MC160002271

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag L7F76_RS23570 Protein ID WP_002886902.1
Coordinates 4757929..4758213 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag L7F76_RS23575 Protein ID WP_002886901.1
Coordinates 4758203..4758445 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7F76_RS23545 (4753345) 4753345..4753608 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
L7F76_RS23550 (4753738) 4753738..4753911 + 174 WP_032408826.1 hypothetical protein -
L7F76_RS23555 (4753914) 4753914..4754657 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
L7F76_RS23560 (4755014) 4755014..4757152 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
L7F76_RS23565 (4757461) 4757461..4757925 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L7F76_RS23570 (4757929) 4757929..4758213 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L7F76_RS23575 (4758203) 4758203..4758445 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L7F76_RS23580 (4758523) 4758523..4760433 - 1911 WP_062921034.1 PRD domain-containing protein -
L7F76_RS23585 (4760456) 4760456..4761610 - 1155 WP_002886900.1 lactonase family protein -
L7F76_RS23590 (4761677) 4761677..4762417 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T234820 WP_002886902.1 NZ_CP091813:c4758213-4757929 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T234820 NZ_LR134090:1893249-1893344 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT234820 WP_002886901.1 NZ_CP091813:c4758445-4758203 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT234820 NZ_LR134090:c1893429-1893372 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References