Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3993681..3994300 Replicon chromosome
Accession NZ_CP091813
Organism Klebsiella pneumoniae strain 10MC160002271

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag L7F76_RS19840 Protein ID WP_002892050.1
Coordinates 3994082..3994300 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag L7F76_RS19835 Protein ID WP_002892066.1
Coordinates 3993681..3994055 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7F76_RS19825 (3988833) 3988833..3990026 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L7F76_RS19830 (3990049) 3990049..3993195 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
L7F76_RS19835 (3993681) 3993681..3994055 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
L7F76_RS19840 (3994082) 3994082..3994300 + 219 WP_002892050.1 HHA domain-containing protein Toxin
L7F76_RS19845 (3994459) 3994459..3995025 + 567 WP_002892030.1 maltose O-acetyltransferase -
L7F76_RS19850 (3994997) 3994997..3995137 - 141 WP_004147370.1 hypothetical protein -
L7F76_RS19855 (3995158) 3995158..3995628 + 471 WP_002892026.1 YlaC family protein -
L7F76_RS19860 (3995603) 3995603..3997054 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
L7F76_RS19865 (3997155) 3997155..3997853 + 699 WP_002892021.1 GNAT family protein -
L7F76_RS19870 (3997850) 3997850..3997990 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
L7F76_RS19875 (3997990) 3997990..3998253 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T234818 WP_002892050.1 NZ_CP091813:3994082-3994300 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T234818 NZ_LR134089:c2600795-2600700 [Staphylococcus saprophyticus]
ATGCTTATGATCTTCGTTCACATCATTGCACCAGTCATTAGTGGCTGTGCAGTTGCGTATTTTACTTATTGGCTTAGTAG
TAAACGCAATAAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT234818 WP_002892066.1 NZ_CP091813:3993681-3994055 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT234818 NZ_LR134089:2600638-2600671 [Staphylococcus saprophyticus]
CACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References