Detailed information of TA system TA234816

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2626729..2628317
• Replicon: chromosome
• Accession: NZ_CP091813
• Organism: Klebsiella pneumoniae strain 10MC160002271

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A486RAG1
• Locus tag: L7F76_RS13120
• Protein ID: WP_016946382.1
• Coordinates: 2626729..2628051 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: L7F76_RS13125
• Protein ID: WP_004176198.1
• Coordinates: 2628051..2628317 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L7F76_RS13105 (2621785)	2621785..2624286	+	2502	WP_062920729.1	fimbria/pilus outer membrane usher protein	-
L7F76_RS13110 (2624274)	2624274..2625278	+	1005	WP_004184029.1	fimbrial protein	-
L7F76_RS13115 (2625420)	2625420..2626712	+	1293	WP_062920730.1	glycoside hydrolase family 10 protein	-
L7F76_RS13120 (2626729)	2626729..2628051	-	1323	WP_016946382.1	type II toxin-antitoxin system HipA family toxin	Toxin
L7F76_RS13125 (2628051)	2628051..2628317	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
L7F76_RS13130 (2628583)	2628583..2628909	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
L7F76_RS13135 (2628906)	2628906..2629406	-	501	WP_062920731.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
L7F76_RS13140 (2629384)	2629384..2630763	-	1380	WP_004176204.1	nucleobase:cation symporter-2 family protein	-
L7F76_RS13145 (2631108)	2631108..2632262	+	1155	WP_023341545.1	FAD-dependent urate hydroxylase HpxO	-
L7F76_RS13150 (2632243)	2632243..2633166	-	924	WP_062920732.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49125.44 Da
• Isoelectric Point: 7.5358

>T234816 WP_016946382.1 NZ_CP091813:c2628051-2626729 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T234816 NZ_LR134089:867985-868347 [Staphylococcus saprophyticus]
ATGATGAGACGTGGTGACGTTTATTTAGCTGATTTATCACCAGTCCAGGGGTCTGAACAAGGGGGAATAAGACCTGTCGT
AATTATACAAAACGATACTGGTAATAAATATAGTCCTACCGTAATTGTAGCCGCAATTACTGGTAGGATAAATAAAGCTA
AAATACCAACACATGTAGAAATAGAAAAAAGTAAATATAAATTAGATAAAGATTCTGTTATATTGCTAGAGCAGATTAGA
ACTTTAGATAAAAATAGGCTGAAAGAAAAATTAACTTATCTTTCTGATAAAAAAATGAAAGAAGTTAATAATGCCATTGA
TATTAGTTTAGGATTACATACTATTAGGAGTCACAAATCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT234816 WP_004176198.1 NZ_CP091813:c2628317-2628051 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT234816 NZ_LR134089:867818-867988 [Staphylococcus saprophyticus]
ATGGCAAGTTTCAACCAAAGTAGAATTCATAGTATAGAACAACTTTTAAAAGAAGGCTATTCTCAAATGGCTGATTTGAA
CCTCTCCCTCGCAGCAGAAGCATTTCCGTTTGAATGTGAAGCTTGTGATTGCAACGAAGTATATATTAGCTCCAAGAATA
ATAATGAATGA

Structures

Toxin

• AlphaFold DB: A0A486RAG1