Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 717228..718005 Replicon chromosome
Accession NC_011852
Organism Haemophilus parasuis SH0165

Toxin (Protein)


Gene name TacT3 Uniprot ID B8F4U7
Locus tag HAPS_RS03430 Protein ID WP_005710654.1
Coordinates 717505..718005 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID U4SPD7
Locus tag HAPS_RS03425 Protein ID WP_005710653.1
Coordinates 717228..717515 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAPS_RS03405 713594..714094 - 501 WP_010786633.1 CvpA family protein -
HAPS_RS03410 714200..715777 - 1578 WP_012621872.1 FAD-binding protein -
HAPS_RS03415 715952..716689 - 738 WP_005710648.1 peptidoglycan editing factor PgeF -
HAPS_RS03420 716693..717082 - 390 WP_012621873.1 RidA family protein -
HAPS_RS03425 717228..717515 + 288 WP_005710653.1 DUF1778 domain-containing protein Antitoxin
HAPS_RS03430 717505..718005 + 501 WP_005710654.1 GNAT family N-acetyltransferase Toxin
HAPS_RS03435 718033..719034 + 1002 WP_005710656.1 nucleoid-associated protein YejK -
HAPS_RS03440 719095..719430 + 336 WP_005710658.1 outer membrane protein assembly factor BamE -
HAPS_RS03445 719585..720700 + 1116 WP_012621874.1 anhydro-N-acetylmuramic acid kinase -
HAPS_RS03450 720712..721626 + 915 WP_012621875.1 N-acetylmuramic acid 6-phosphate etherase -
HAPS_RS03455 721668..721982 + 315 WP_005710664.1 YqcC family protein -
HAPS_RS03460 721979..722707 + 729 WP_012621876.1 tRNA pseudouridine(65) synthase TruC -
HAPS_RS11460 722725..722880 + 156 WP_012621877.1 YoaH family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(4-87)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 19184.39 Da        Isoelectric Point: 9.3198

>T23481 WP_005710654.1 NC_011852:717505-718005 [Glaesserella parasuis SH0165]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYARQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYHPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVWGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Download         Length: 501 bp

>T23481 NC_011852:717505-718005 [Glaesserella parasuis SH0165]
ATGAAGAGTAAGTTTATTGAAGAGCCTTTAACGAAGCATCATCAACGTGAAGCCTTTGATTGCGGAAATCTAGAGATGAA
CCGATTTTTTAAACAATACGCTCGGCAATCTCACGAAAAAGGGACATCAAAAACTTACATTAGCCGACACTTAGACAGTC
AACAGATTATCGGATTTTATACAATCACCTTAAGTGCATTAGACCAGCAACACTTACCCGAACTATGCAAAAAACGTTTT
GGCTACCACCCTATTCCGCTCTTTACATTAGCAAGACTTGCAGTGGATATTCGCTATCAAAAACAAGGCATTGGCGGAAT
GCTGTTGGTTAAAGCTCTCAAACGCTGTGCCATCGTTGCCGAACAAGTCTGGGGAATTGGGCTTCTCATTGAAGCAAAAG
ATGAAGACATTTCTCGTTGGTATCAATCTTATGGTGCTATTCCATTGGAAAATATGCCATTAACCTTAATTCTACTCTTT
GATACAATCAAAGGACTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10917.47 Da        Isoelectric Point: 6.4650

>AT23481 WP_005710653.1 NC_011852:717228-717515 [Glaesserella parasuis SH0165]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Download         Length: 288 bp

>AT23481 NC_011852:717228-717515 [Glaesserella parasuis SH0165]
ATGCCACAAATTGCAAATGCCCTTAACGATAGAATGTCTATTCGCATTAGTACGGAAGACAAGCAGACTTTAATTAGAGC
CGTTGCACTTACCCATACGAATATTACGGAATTTGTATTACAACGTATTTTGCCTAGTGCCAGAGAAATTATTCAGCAGT
ATGATAATCGGCAATTTTCACCGCAAGATCTCTCGTTGATTATGGAATTGCTTGATAATCCGCCGAAAGCTAATACAAAA
CTACAACAAGCGGCGAAATTAGCAAAGGAAAGCTATCATGAAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YZP3

Antitoxin

Source ID Structure
AlphaFold DB U4SPD7

References