Detailed information of TA system TA023480

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 622270..622809
• Replicon: chromosome
• Accession: NC_011852
• Organism: Haemophilus parasuis SH0165

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B8F4J8
• Locus tag: HAPS_RS02940
• Protein ID: WP_010786322.1
• Coordinates: 622270..622539 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B8F4J9
• Locus tag: HAPS_RS02945
• Protein ID: WP_005714576.1
• Coordinates: 622543..622809 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAPS_RS02920	617636..617968	-	333	WP_010786325.1	phage tail protein	-
HAPS_RS02925	618013..621387	-	3375	WP_012621825.1	phage tail tape measure protein	-
HAPS_RS02930	621443..621718	-	276	WP_005714514.1	hypothetical protein	-
HAPS_RS02935	621920..622186	-	267	WP_010786323.1	hypothetical protein	-
HAPS_RS02940	622270..622539	-	270	WP_010786322.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HAPS_RS02945	622543..622809	-	267	WP_005714576.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HAPS_RS02950	622878..623105	-	228	WP_005714573.1	DUF4035 domain-containing protein	-
HAPS_RS02955	623150..623551	-	402	WP_005714571.1	hypothetical protein	-
HAPS_RS02960	623625..624290	-	666	WP_012621826.1	hypothetical protein	-
HAPS_RS02965	624293..624712	-	420	WP_005714567.1	phage tail protein	-
HAPS_RS02970	624712..625245	-	534	WP_012621827.1	phage tail protein	-
HAPS_RS02975	625249..625551	-	303	WP_012621828.1	phage tail protein	-
HAPS_RS02980	625544..625870	-	327	WP_012621829.1	DUF2190 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	577636..651927	74291

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-80)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10294.03 Da
• Isoelectric Point: 6.8591

>T23480 WP_010786322.1 NC_011852:c622539-622270 [Glaesserella parasuis SH0165]
MLQLSPTNAYKRDFKKIASELMASAEYIEVMYCLMHQLPLAEKYKDHPLQGELQGFRDCHIKPDLVLIYAVENNLLRLVR
LGSHSELFG

Nucleotide

• Length: 270 bp

>T23480 NC_011852:c622539-622270 [Glaesserella parasuis SH0165]
ATGTTACAACTTTCTCCAACAAATGCTTATAAAAGAGATTTTAAAAAGATTGCTTCTGAGTTAATGGCTAGTGCCGAATA
TATAGAAGTGATGTATTGTTTAATGCATCAGTTACCTTTGGCGGAGAAATATAAAGATCACCCATTACAAGGAGAATTAC
AAGGTTTTAGAGATTGCCATATCAAACCTGATCTTGTTTTGATTTATGCGGTTGAAAATAATTTACTTCGCTTGGTACGT
TTAGGATCACATTCCGAATTATTTGGGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9945.38 Da
• Isoelectric Point: 5.0366

>AT23480 WP_005714576.1 NC_011852:c622809-622543 [Glaesserella parasuis SH0165]
MATINDAFSFRTNTEVKNTAFEVIKSYGMTPSQVFNMLLTEIAYTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYESLEA
FHKAMLAE

Nucleotide

• Length: 267 bp

>AT23480 NC_011852:c622809-622543 [Glaesserella parasuis SH0165]
ATGGCGACCATTAATGATGCTTTCAGTTTTAGAACAAACACAGAAGTTAAAAATACGGCTTTTGAAGTGATAAAAAGTTA
TGGAATGACTCCATCACAAGTGTTTAATATGCTTCTCACTGAAATTGCATATACTAAAACAATTCCGTTAAGTTTGAATT
ATCAACCAAACCTTGAGACTAAGTTGGCAATGCAGGAAGCTAAATCAGGTAAAAATGAAGTATATGAATCTTTGGAAGCG
TTTCATAAAGCAATGTTAGCGGAGTAA

Structures

Toxin

• AlphaFold DB: B8F4J8

Antitoxin

• AlphaFold DB: B8F4J9