Detailed information of TA system TA234799

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4737808..4738321
• Replicon: chromosome
• Accession: NZ_CP091805
• Organism: Klebsiella quasipneumoniae strain 21223

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L7H25_RS23020
• Protein ID: WP_064190102.1
• Coordinates: 4737808..4738089 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: L7H25_RS23025
• Protein ID: WP_002886901.1
• Coordinates: 4738079..4738321 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L7H25_RS23005 (4732850)	4732850..4734505	+	1656	WP_064178460.1	alpha,alpha-phosphotrehalase	-
L7H25_RS23010 (4734891)	4734891..4737029	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
L7H25_RS23015 (4737340)	4737340..4737804	+	465	WP_064190101.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
L7H25_RS23020 (4737808)	4737808..4738089	-	282	WP_064190102.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L7H25_RS23025 (4738079)	4738079..4738321	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
L7H25_RS23030 (4738399)	4738399..4740309	-	1911	WP_057212387.1	PRD domain-containing protein	-
L7H25_RS23035 (4740332)	4740332..4741483	-	1152	WP_065878155.1	lactonase family protein	-
L7H25_RS23040 (4741550)	4741550..4742290	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11031.81 Da
• Isoelectric Point: 10.1752

>T234799 WP_064190102.1 NZ_CP091805:c4738089-4737808 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNNLQQIMQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T234799 NZ_LR134086:c1946389-1946237 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAAGTAAAGAAATGGAACAAATTTCCGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT234799 WP_002886901.1 NZ_CP091805:c4738321-4738079 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT234799 NZ_LR134086:c1947013-1946414 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0