Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4008683..4009302 Replicon chromosome
Accession NZ_CP091805
Organism Klebsiella quasipneumoniae strain 21223

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag L7H25_RS19555 Protein ID WP_002892050.1
Coordinates 4009084..4009302 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag L7H25_RS19550 Protein ID WP_002892066.1
Coordinates 4008683..4009057 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7H25_RS19540 (4003836) 4003836..4005029 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L7H25_RS19545 (4005052) 4005052..4008198 + 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit AcrB -
L7H25_RS19550 (4008683) 4008683..4009057 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
L7H25_RS19555 (4009084) 4009084..4009302 + 219 WP_002892050.1 HHA domain-containing protein Toxin
L7H25_RS19560 (4009460) 4009460..4010026 + 567 WP_004204750.1 maltose O-acetyltransferase -
L7H25_RS19565 (4009998) 4009998..4010120 - 123 WP_032426076.1 hypothetical protein -
L7H25_RS19570 (4010163) 4010163..4010633 + 471 WP_004204751.1 YlaC family protein -
L7H25_RS19575 (4010602) 4010602..4012059 - 1458 WP_065903537.1 PLP-dependent aminotransferase family protein -
L7H25_RS19580 (4012160) 4012160..4012858 + 699 WP_064187826.1 GNAT family protein -
L7H25_RS19585 (4012855) 4012855..4012995 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
L7H25_RS19590 (4012995) 4012995..4013258 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T234798 WP_002892050.1 NZ_CP091805:4009084-4009302 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T234798 NZ_LR134086:1905199-1905294 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT234798 WP_002892066.1 NZ_CP091805:4008683-4009057 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT234798 NZ_LR134086:c1905378-1905322 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References