Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 848788..849445 Replicon chromosome
Accession NZ_CP091805
Organism Klebsiella quasipneumoniae strain 21223

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag L7H25_RS04185 Protein ID WP_004205323.1
Coordinates 849035..849445 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag L7H25_RS04180 Protein ID WP_002916312.1
Coordinates 848788..849054 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7H25_RS04155 (843939) 843939..845372 - 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -
L7H25_RS04160 (845491) 845491..846219 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
L7H25_RS04165 (846269) 846269..846580 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
L7H25_RS04170 (846743) 846743..847402 + 660 WP_004205319.1 hemolysin III family protein -
L7H25_RS04175 (847559) 847559..848542 - 984 WP_049116109.1 tRNA-modifying protein YgfZ -
L7H25_RS04180 (848788) 848788..849054 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
L7H25_RS04185 (849035) 849035..849445 + 411 WP_004205323.1 protein YgfX Toxin
L7H25_RS04190 (849452) 849452..849973 - 522 WP_004205324.1 flavodoxin FldB -
L7H25_RS04195 (850074) 850074..850970 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
L7H25_RS04200 (850993) 850993..851706 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L7H25_RS04205 (851712) 851712..853445 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T234788 WP_004205323.1 NZ_CP091805:849035-849445 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T234788 NZ_LR134085:c2063833-2063657 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT234788 WP_002916312.1 NZ_CP091805:848788-849054 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT234788 NZ_LR134085:2063526-2063667 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References