Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 1762340..1762956 | Replicon | chromosome |
Accession | NZ_CP091791 | ||
Organism | Prevotella communis strain E2-25 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | L6470_RS06935 | Protein ID | WP_237850339.1 |
Coordinates | 1762340..1762612 (+) | Length | 91 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | L6470_RS06940 | Protein ID | WP_237792831.1 |
Coordinates | 1762615..1762956 (+) | Length | 114 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L6470_RS06900 (L6470_06900) | 1757894..1758058 | + | 165 | WP_237850333.1 | hypothetical protein | - |
L6470_RS06905 (L6470_06905) | 1758253..1759224 | + | 972 | WP_237851755.1 | DNA adenine methylase | - |
L6470_RS06910 (L6470_06910) | 1759277..1760056 | + | 780 | WP_237850334.1 | hypothetical protein | - |
L6470_RS06915 (L6470_06915) | 1760064..1760336 | + | 273 | WP_237850335.1 | hypothetical protein | - |
L6470_RS06920 (L6470_06920) | 1760338..1760871 | + | 534 | WP_237850336.1 | hypothetical protein | - |
L6470_RS06925 (L6470_06925) | 1760868..1761749 | + | 882 | WP_237850337.1 | site-specific DNA-methyltransferase | - |
L6470_RS06930 (L6470_06930) | 1761957..1762139 | + | 183 | WP_237850338.1 | hypothetical protein | - |
L6470_RS06935 (L6470_06935) | 1762340..1762612 | + | 273 | WP_237850339.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
L6470_RS06940 (L6470_06940) | 1762615..1762956 | + | 342 | WP_237792831.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
L6470_RS06945 (L6470_06945) | 1763165..1763710 | + | 546 | WP_237850340.1 | DNA-directed RNA polymerase subunit alpha C-terminal domain-containing protein | - |
L6470_RS06950 (L6470_06950) | 1763832..1764242 | - | 411 | WP_237833717.1 | Hsp20/alpha crystallin family protein | - |
L6470_RS06955 (L6470_06955) | 1764537..1765880 | + | 1344 | WP_237850341.1 | right-handed parallel beta-helix repeat-containing protein | - |
L6470_RS06960 (L6470_06960) | 1765877..1766350 | - | 474 | WP_091818702.1 | cytidine deaminase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10520.09 Da Isoelectric Point: 9.6425
>T234786 WP_237850339.1 NZ_CP091791:1762340-1762612 [Prevotella communis]
MNKKDKLLQRFKNLPRDFTFEEMEALFKCCGFTLNNKGATSGSRVEFVNEKDGNSYIMHKPHPSNIIKGYSMKQIYTYLD
ANGYLKKKEE
MNKKDKLLQRFKNLPRDFTFEEMEALFKCCGFTLNNKGATSGSRVEFVNEKDGNSYIMHKPHPSNIIKGYSMKQIYTYLD
ANGYLKKKEE
Download Length: 273 bp
>T234786 NZ_LR134085:1903261-1903356 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG
Antitoxin
Download Length: 114 a.a. Molecular weight: 12455.04 Da Isoelectric Point: 4.8666
>AT234786 WP_237792831.1 NZ_CP091791:1762615-1762956 [Prevotella communis]
MGFLKYKGYTGSVEYSEEDNCLFGKVQGMSKHTITYEGQTLDELRQDFEGAVEDYLASCAERGVEPCKPYSGTFNVRVSP
EIHSAIAAMAQQAGVTINAFVRQVLAKEAKLAY
MGFLKYKGYTGSVEYSEEDNCLFGKVQGMSKHTITYEGQTLDELRQDFEGAVEDYLASCAERGVEPCKPYSGTFNVRVSP
EIHSAIAAMAQQAGVTINAFVRQVLAKEAKLAY
Download Length: 342 bp
>AT234786 NZ_LR134085:c1903443-1903384 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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