Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/-
Location 1762340..1762956 Replicon chromosome
Accession NZ_CP091791
Organism Prevotella communis strain E2-25

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag L6470_RS06935 Protein ID WP_237850339.1
Coordinates 1762340..1762612 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L6470_RS06940 Protein ID WP_237792831.1
Coordinates 1762615..1762956 (+) Length 114 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6470_RS06900 (L6470_06900) 1757894..1758058 + 165 WP_237850333.1 hypothetical protein -
L6470_RS06905 (L6470_06905) 1758253..1759224 + 972 WP_237851755.1 DNA adenine methylase -
L6470_RS06910 (L6470_06910) 1759277..1760056 + 780 WP_237850334.1 hypothetical protein -
L6470_RS06915 (L6470_06915) 1760064..1760336 + 273 WP_237850335.1 hypothetical protein -
L6470_RS06920 (L6470_06920) 1760338..1760871 + 534 WP_237850336.1 hypothetical protein -
L6470_RS06925 (L6470_06925) 1760868..1761749 + 882 WP_237850337.1 site-specific DNA-methyltransferase -
L6470_RS06930 (L6470_06930) 1761957..1762139 + 183 WP_237850338.1 hypothetical protein -
L6470_RS06935 (L6470_06935) 1762340..1762612 + 273 WP_237850339.1 type II toxin-antitoxin system HicA family toxin Toxin
L6470_RS06940 (L6470_06940) 1762615..1762956 + 342 WP_237792831.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L6470_RS06945 (L6470_06945) 1763165..1763710 + 546 WP_237850340.1 DNA-directed RNA polymerase subunit alpha C-terminal domain-containing protein -
L6470_RS06950 (L6470_06950) 1763832..1764242 - 411 WP_237833717.1 Hsp20/alpha crystallin family protein -
L6470_RS06955 (L6470_06955) 1764537..1765880 + 1344 WP_237850341.1 right-handed parallel beta-helix repeat-containing protein -
L6470_RS06960 (L6470_06960) 1765877..1766350 - 474 WP_091818702.1 cytidine deaminase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(21-78)

Antitoxin

(55-105)


Sequences


Toxin        


Download         Length: 91 a.a.        Molecular weight: 10520.09 Da        Isoelectric Point: 9.6425

>T234786 WP_237850339.1 NZ_CP091791:1762340-1762612 [Prevotella communis]
MNKKDKLLQRFKNLPRDFTFEEMEALFKCCGFTLNNKGATSGSRVEFVNEKDGNSYIMHKPHPSNIIKGYSMKQIYTYLD
ANGYLKKKEE

Download         Length: 273 bp

>T234786 NZ_LR134085:1903261-1903356 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12455.04 Da        Isoelectric Point: 4.8666

>AT234786 WP_237792831.1 NZ_CP091791:1762615-1762956 [Prevotella communis]
MGFLKYKGYTGSVEYSEEDNCLFGKVQGMSKHTITYEGQTLDELRQDFEGAVEDYLASCAERGVEPCKPYSGTFNVRVSP
EIHSAIAAMAQQAGVTINAFVRQVLAKEAKLAY

Download         Length: 342 bp

>AT234786 NZ_LR134085:c1903443-1903384 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References