Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 513817..514391 Replicon chromosome
Accession NZ_CP091785
Organism Brucella pseudogrignonensis strain ESL2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L7D45_RS21950 Protein ID WP_200637029.1
Coordinates 514014..514391 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L7D45_RS21945 Protein ID WP_171380402.1
Coordinates 513817..514017 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7D45_RS21930 (L7D45_21930) 508851..509624 - 774 WP_237854405.1 ABC transporter ATP-binding protein -
L7D45_RS21935 (L7D45_21935) 509858..512044 + 2187 WP_200637031.1 TonB-dependent siderophore receptor -
L7D45_RS21940 (L7D45_21940) 512089..513444 - 1356 WP_094544439.1 PLP-dependent aminotransferase family protein -
L7D45_RS21945 (L7D45_21945) 513817..514017 + 201 WP_171380402.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L7D45_RS21950 (L7D45_21950) 514014..514391 + 378 WP_200637029.1 type II toxin-antitoxin system VapC family toxin Toxin
L7D45_RS21955 (L7D45_21955) 514551..516287 - 1737 WP_200637027.1 ABC transporter ATP-binding protein -
L7D45_RS21960 (L7D45_21960) 516280..517284 - 1005 WP_237854407.1 ABC transporter ATP-binding protein -
L7D45_RS21965 (L7D45_21965) 517281..518321 - 1041 WP_200637023.1 iron chelate uptake ABC transporter family permease subunit -
L7D45_RS21970 (L7D45_21970) 518318..519358 - 1041 WP_200637021.1 iron chelate uptake ABC transporter family permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14058.29 Da        Isoelectric Point: 5.9730

>T234785 WP_200637029.1 NZ_CP091785:514014-514391 [Brucella pseudogrignonensis]
VILADTSIWIDHFRSGDNELIKIIADDLLLCHPAIIGELALGSLRDRTSVLAFLNVQREAQVATHDEVMTMIEMHCIFSM
GIGYTDAQLLASVLLDRRTSLWTRDKRLKVTAEKAGARLYEPLHN

Download         Length: 378 bp

>T234785 NZ_LR134085:c896512-896324 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7273.53 Da        Isoelectric Point: 11.5333

>AT234785 WP_171380402.1 NZ_CP091785:513817-514017 [Brucella pseudogrignonensis]
MRSTINLDDNLLEKARLLTGTKETAALVRQALETLVRLETGKRLIALGGTMPNVEAAPRRRSSVKK

Download         Length: 201 bp

>AT234785 NZ_LR134085:c896801-896541 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References