Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 504109..504707 Replicon chromosome
Accession NZ_CP091785
Organism Brucella pseudogrignonensis strain ESL2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L7D45_RS21900 Protein ID WP_200637038.1
Coordinates 504109..504402 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag L7D45_RS21905 Protein ID WP_200637037.1
Coordinates 504399..504707 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7D45_RS21875 (L7D45_21875) 500954..501976 - 1023 WP_237854402.1 FecR family protein -
L7D45_RS21880 (L7D45_21880) 502081..502596 - 516 WP_200637043.1 sigma-70 family RNA polymerase sigma factor -
L7D45_RS21885 (L7D45_21885) 502899..503351 - 453 WP_200637257.1 hypothetical protein -
L7D45_RS21890 (L7D45_21890) 503338..503538 + 201 WP_200637042.1 type II toxin-antitoxin system VapB family antitoxin -
L7D45_RS21895 (L7D45_21895) 503535..503912 + 378 WP_200637040.1 type II toxin-antitoxin system VapC family toxin -
L7D45_RS21900 (L7D45_21900) 504109..504402 - 294 WP_200637038.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L7D45_RS21905 (L7D45_21905) 504399..504707 - 309 WP_200637037.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L7D45_RS21910 (L7D45_21910) 505147..505881 + 735 WP_237854403.1 sucrase ferredoxin -
L7D45_RS21915 (L7D45_21915) 505889..506821 - 933 WP_200637035.1 ABC transporter substrate-binding protein -
L7D45_RS21920 (L7D45_21920) 506818..507855 - 1038 WP_007881790.1 iron ABC transporter permease -
L7D45_RS21925 (L7D45_21925) 507855..508838 - 984 WP_200637033.1 iron ABC transporter permease -
L7D45_RS21930 (L7D45_21930) 508851..509624 - 774 WP_237854405.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-57)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10597.19 Da        Isoelectric Point: 8.6391

>T234784 WP_200637038.1 NZ_CP091785:c504402-504109 [Brucella pseudogrignonensis]
VKLTWSAFALSDRDAIFTFIEAENPSSAIMVDERIVAAARRLIDFPASGRVGRIAGTRELVINGTPYVAAYAVTQSAVRI
LRVLHGAREWPDIIPTS

Download         Length: 294 bp

>T234784 NZ_LR134082:c4208476-4208303 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11162.66 Da        Isoelectric Point: 6.2296

>AT234784 WP_200637037.1 NZ_CP091785:c504707-504399 [Brucella pseudogrignonensis]
MASNALVQTRIDAEVRDRASAVLESMGLTVSDVVRILLTRTANEGALPLELISGSEAHDAWFRSKVLEALHDTRPDLPDD
EVTAHFERRRAAARLKAAALKS

Download         Length: 309 bp

>AT234784 NZ_LR134082:c4208800-4208504 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References