Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 503338..503912 Replicon chromosome
Accession NZ_CP091785
Organism Brucella pseudogrignonensis strain ESL2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L7D45_RS21895 Protein ID WP_200637040.1
Coordinates 503535..503912 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L7D45_RS21890 Protein ID WP_200637042.1
Coordinates 503338..503538 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7D45_RS21875 (L7D45_21875) 500954..501976 - 1023 WP_237854402.1 FecR family protein -
L7D45_RS21880 (L7D45_21880) 502081..502596 - 516 WP_200637043.1 sigma-70 family RNA polymerase sigma factor -
L7D45_RS21885 (L7D45_21885) 502899..503351 - 453 WP_200637257.1 hypothetical protein -
L7D45_RS21890 (L7D45_21890) 503338..503538 + 201 WP_200637042.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L7D45_RS21895 (L7D45_21895) 503535..503912 + 378 WP_200637040.1 type II toxin-antitoxin system VapC family toxin Toxin
L7D45_RS21900 (L7D45_21900) 504109..504402 - 294 WP_200637038.1 type II toxin-antitoxin system RelE/ParE family toxin -
L7D45_RS21905 (L7D45_21905) 504399..504707 - 309 WP_200637037.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
L7D45_RS21910 (L7D45_21910) 505147..505881 + 735 WP_237854403.1 sucrase ferredoxin -
L7D45_RS21915 (L7D45_21915) 505889..506821 - 933 WP_200637035.1 ABC transporter substrate-binding protein -
L7D45_RS21920 (L7D45_21920) 506818..507855 - 1038 WP_007881790.1 iron ABC transporter permease -
L7D45_RS21925 (L7D45_21925) 507855..508838 - 984 WP_200637033.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13942.11 Da        Isoelectric Point: 6.3254

>T234783 WP_200637040.1 NZ_CP091785:503535-503912 [Brucella pseudogrignonensis]
VILADTSIWIDHFRSGDNELIKIIADDLLLCHPAIIGELALGSLRDRTSVLAFLNVQREAQAATHDEVMTMIEKHCIFSM
GIGYTDAQLLASVLLDRRASLWTRDKRLKATAEKAGARLYEPLHS

Download         Length: 378 bp

>T234783 NZ_LR134082:c4048145-4047771 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7274.52 Da        Isoelectric Point: 11.2132

>AT234783 WP_200637042.1 NZ_CP091785:503338-503538 [Brucella pseudogrignonensis]
MRSTINLDDNLLEKARLLTGTKETAALVRQALETLVRLETGKRLIALGGTMPDVEAAPRRRSSVKK

Download         Length: 201 bp

>AT234783 NZ_LR134082:c4048603-4048235 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References