Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 118589..119268 Replicon chromosome
Accession NZ_CP091785
Organism Brucella pseudogrignonensis strain ESL2

Toxin (Protein)


Gene name vapC Uniprot ID A0A1A9FUC3
Locus tag L7D45_RS20160 Protein ID WP_064323174.1
Coordinates 118589..119014 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1A9FU95
Locus tag L7D45_RS20165 Protein ID WP_007880986.1
Coordinates 119011..119268 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L7D45_RS20130 (L7D45_20130) 113898..115199 + 1302 WP_113159500.1 FAD-binding oxidoreductase -
L7D45_RS20135 (L7D45_20135) 115235..115714 + 480 WP_064323171.1 L-2-amino-thiazoline-4-carboxylic acid hydrolase -
L7D45_RS20140 (L7D45_20140) 115716..116882 + 1167 WP_200636881.1 M20 aminoacylase family protein -
L7D45_RS20145 (L7D45_20145) 116970..117233 + 264 Protein_107 transposase -
L7D45_RS20150 (L7D45_20150) 117295..117582 + 288 Protein_108 type II toxin-antitoxin system RelE/ParE family toxin -
L7D45_RS20155 (L7D45_20155) 117996..118363 + 368 Protein_109 recombinase family protein -
L7D45_RS20160 (L7D45_20160) 118589..119014 - 426 WP_064323174.1 type II toxin-antitoxin system VapC family toxin Toxin
L7D45_RS20165 (L7D45_20165) 119011..119268 - 258 WP_007880986.1 hypothetical protein Antitoxin
L7D45_RS20170 (L7D45_20170) 119395..120405 - 1011 WP_064323175.1 IS30 family transposase -
L7D45_RS20175 (L7D45_20175) 121159..122103 + 945 WP_112807751.1 sugar-binding transcriptional regulator -
L7D45_RS20180 (L7D45_20180) 122131..123573 + 1443 WP_064323177.1 extracellular solute-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15405.62 Da        Isoelectric Point: 5.5742

>T234781 WP_064323174.1 NZ_CP091785:c119014-118589 [Brucella pseudogrignonensis]
MIVIDTNVISEMWKVEPHPDALTWFDAQAIETLYLSAITVAELRYGLAAMPEGKRRTIYQQRLEHEVLPAFAGRVLAFDL
ATTKHYADLMAQARTSGKAIANADGYIAATAAAHGFIVATRDTSPFRAAGLEVIDPWATSV

Download         Length: 426 bp

>T234781 NZ_LR134082:c3663353-3662955 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9393.64 Da        Isoelectric Point: 7.4064

>AT234781 WP_007880986.1 NZ_CP091785:c119268-119011 [Brucella pseudogrignonensis]
MANVTVRNLPDAVHRALRVRAAHHGRSTEAEIREILETAARPPQRVKLGSLLASIAREAGGLTDEEHAVFDSVRDKTPAE
PMRFE

Download         Length: 258 bp

>AT234781 NZ_LR134082:c3663649-3663356 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A9FUC3

Antitoxin

Source ID Structure
AlphaFold DB A0A1A9FU95

References