Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 4644684..4645300 Replicon chromosome
Accession NZ_CP091779
Organism Enterobacter mori strain ACYC.E9L

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L6Y89_RS21970 Protein ID WP_237845167.1
Coordinates 4644684..4645055 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L6Y89_RS21975 Protein ID WP_237845168.1
Coordinates 4645058..4645300 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6Y89_RS21955 (L6Y89_21955) 4642184..4643086 + 903 WP_010436855.1 formate dehydrogenase subunit beta -
L6Y89_RS21960 (L6Y89_21960) 4643083..4643718 + 636 WP_010436852.1 formate dehydrogenase cytochrome b556 subunit -
L6Y89_RS21965 (L6Y89_21965) 4643715..4644644 + 930 WP_010436850.1 formate dehydrogenase accessory protein FdhE -
L6Y89_RS21970 (L6Y89_21970) 4644684..4645055 - 372 WP_237845167.1 type II toxin-antitoxin system VapC family toxin Toxin
L6Y89_RS21975 (L6Y89_21975) 4645058..4645300 - 243 WP_237845168.1 CopG family transcriptional regulator Antitoxin
L6Y89_RS21980 (L6Y89_21980) 4645500..4646417 + 918 WP_237845169.1 alpha/beta hydrolase -
L6Y89_RS21985 (L6Y89_21985) 4646430..4647371 - 942 WP_010436842.1 fatty acid biosynthesis protein FabY -
L6Y89_RS21990 (L6Y89_21990) 4647416..4647853 - 438 WP_108417975.1 D-aminoacyl-tRNA deacylase -
L6Y89_RS21995 (L6Y89_21995) 4647850..4648731 - 882 WP_237845170.1 virulence factor BrkB family protein -
L6Y89_RS22000 (L6Y89_22000) 4648725..4649324 - 600 WP_010436834.1 glucose-1-phosphatase -
L6Y89_RS22005 (L6Y89_22005) 4649443..4650243 - 801 WP_237845171.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13587.74 Da        Isoelectric Point: 6.9793

>T234780 WP_237845167.1 NZ_CP091779:c4645055-4644684 [Enterobacter mori]
MEHMAVFDTNILIDLFNNRVEAADAIDRTASHRAISLITWMEVMVGARKHGHEAKTAAVMGAFEIIEISREIAERSVLLR
EKHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYQL

Download         Length: 372 bp

>T234780 NZ_CP091779:c4645055-4644684 [Enterobacter mori]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATCGATCTTTTTAATAATCGCGTTGAGGCGGCGGATGCCATTGA
TCGCACGGCGTCGCATAGAGCCATTAGCCTGATCACATGGATGGAAGTCATGGTTGGCGCGCGCAAGCACGGACATGAAG
CAAAAACGGCGGCTGTGATGGGGGCTTTTGAAATTATTGAGATCTCGCGGGAGATAGCTGAAAGAAGCGTATTACTCCGC
GAGAAGCACGGCATGAAGCTGCCCGATGCCATCATTCTGGCTACCGCTCAGAGCAGAAGTTGCCCGTTAATCTCACGCAA
TACGAAAGACTTTTCGGGCATTGCCGGGGTCGTTTCACCTTACCAGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9427.59 Da        Isoelectric Point: 4.1735

>AT234780 WP_237845168.1 NZ_CP091779:c4645300-4645058 [Enterobacter mori]
MSLLADLDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIEQYLDQQSSSVIRDALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT234780 NZ_CP091779:c4645300-4645058 [Enterobacter mori]
ATGAGTCTTTTGGCGGACCTTGATATGGGCAGAATACTGATCGATTTGTCAGATGATGTGATTCAACGGCTGGATAACCT
GAAGCAGTTGCGAAACCAGCCTCGCGCCGAATTGCTTCGGGAAGCTATTGAGCAATATCTCGACCAGCAGAGTTCATCGG
TTATCCGCGATGCGCTTGGCCTGTGGGGAAACCAGCAGGAAGATGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References