Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4524930..4525534 Replicon chromosome
Accession NZ_CP091779
Organism Enterobacter mori strain ACYC.E9L

Toxin (Protein)


Gene name hicA Uniprot ID A0A7H0N5B9
Locus tag L6Y89_RS21425 Protein ID WP_071993467.1
Coordinates 4525349..4525534 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L6Y89_RS21420 Protein ID WP_237845125.1
Coordinates 4524930..4525334 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6Y89_RS21405 (L6Y89_21405) 4520471..4521289 - 819 WP_237845122.1 helix-turn-helix domain-containing protein -
L6Y89_RS21410 (L6Y89_21410) 4521515..4522915 + 1401 WP_237845123.1 MFS transporter -
L6Y89_RS21415 (L6Y89_21415) 4522926..4524875 + 1950 WP_237845124.1 glycoside hydrolase family 127 protein -
L6Y89_RS21420 (L6Y89_21420) 4524930..4525334 - 405 WP_237845125.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L6Y89_RS21425 (L6Y89_21425) 4525349..4525534 - 186 WP_071993467.1 type II toxin-antitoxin system HicA family toxin Toxin
L6Y89_RS21430 (L6Y89_21430) 4525744..4526484 - 741 WP_237845126.1 MipA/OmpV family protein -
L6Y89_RS21435 (L6Y89_21435) 4526602..4527567 + 966 WP_237845127.1 LysR family transcriptional regulator -
L6Y89_RS21440 (L6Y89_21440) 4527564..4529102 - 1539 WP_237845128.1 aldehyde dehydrogenase family protein -
L6Y89_RS21445 (L6Y89_21445) 4529268..4530152 + 885 WP_237845129.1 ROK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6882.06 Da        Isoelectric Point: 11.2341

>T234779 WP_071993467.1 NZ_CP091779:c4525534-4525349 [Enterobacter mori]
VKSADVITVLISHGWKCVRTKGSHHQFRHPEQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T234779 NZ_LR134082:2618919-2619026 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14986.71 Da        Isoelectric Point: 4.3197

>AT234779 WP_237845125.1 NZ_CP091779:c4525334-4524930 [Enterobacter mori]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTSHFEALFEMDDALPLPGNVEAHLESRPEDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSYVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT234779 NZ_LR134082:c2618872-2618806 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0N5B9

Antitoxin

Source ID Structure

References