Detailed information of TA system TA234777

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3784561..3785218
• Replicon: chromosome
• Accession: NZ_CP091779
• Organism: Enterobacter mori strain ACYC.E9L

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L6Y89_RS17830
• Protein ID: WP_237844802.1
• Coordinates: 3784561..3784971 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V3PWU7
• Locus tag: L6Y89_RS17835
• Protein ID: WP_010435322.1
• Coordinates: 3784952..3785218 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6Y89_RS17810 (L6Y89_17810)	3780553..3782286	-	1734	WP_237844801.1	single-stranded-DNA-specific exonuclease RecJ	-
L6Y89_RS17815 (L6Y89_17815)	3782292..3783005	-	714	WP_010435313.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
L6Y89_RS17820 (L6Y89_17820)	3783034..3783930	-	897	WP_089600303.1	site-specific tyrosine recombinase XerD	-
L6Y89_RS17825 (L6Y89_17825)	3784032..3784553	+	522	WP_010435318.1	flavodoxin FldB	-
L6Y89_RS17830 (L6Y89_17830)	3784561..3784971	-	411	WP_237844802.1	protein YgfX	Toxin
L6Y89_RS17835 (L6Y89_17835)	3784952..3785218	-	267	WP_010435322.1	FAD assembly factor SdhE	Antitoxin
L6Y89_RS17840 (L6Y89_17840)	3785513..3786493	+	981	WP_237844803.1	tRNA-modifying protein YgfZ	-
L6Y89_RS17845 (L6Y89_17845)	3786574..3787233	-	660	WP_003863433.1	hemolysin III family protein	-
L6Y89_RS17850 (L6Y89_17850)	3787499..3788230	+	732	WP_010435329.1	MurR/RpiR family transcriptional regulator	-
L6Y89_RS17855 (L6Y89_17855)	3788348..3789781	+	1434	WP_089600032.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16201.11 Da
• Isoelectric Point: 11.5020

>T234777 WP_237844802.1 NZ_CP091779:c3784971-3784561 [Enterobacter mori]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEIVGTPWMLSVGMMLRLRQPEGGRRQHLWLAADSMDVAEWRDLRRMMLQQPTQD

Nucleotide

• Length: 411 bp

>T234777 NZ_LR134082:c2415414-2415238 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10555.02 Da
• Isoelectric Point: 5.1340

>AT234777 WP_010435322.1 NZ_CP091779:c3785218-3784952 [Enterobacter mori]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT234777 NZ_LR134082:c2415192-2414776 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Antitoxin

• AlphaFold DB: V3PWU7