Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-stbD/ParE-DnaT
Location 29843..30378 Replicon chromosome
Accession NC_011852
Organism Haemophilus parasuis SH0165

Toxin (Protein)


Gene name relE Uniprot ID B8F327
Locus tag HAPS_RS00120 Protein ID WP_012621505.1
Coordinates 30094..30378 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A836Z1U9
Locus tag HAPS_RS00115 Protein ID WP_010785924.1
Coordinates 29843..30097 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAPS_RS00095 25428..25970 + 543 WP_005712695.1 adenine phosphoribosyltransferase -
HAPS_RS00100 26035..28047 + 2013 WP_012621502.1 DNA polymerase III subunit gamma/tau -
HAPS_RS00105 28053..28949 + 897 WP_005712691.1 ABC transporter ATP-binding protein -
HAPS_RS00110 28971..29726 + 756 WP_012621503.1 ABC transporter permease -
HAPS_RS00115 29843..30097 + 255 WP_010785924.1 plasmid stability protein StbD Antitoxin
HAPS_RS00120 30094..30378 + 285 WP_012621505.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HAPS_RS00125 30588..32138 + 1551 WP_041603091.1 exodeoxyribonuclease I -
HAPS_RS00130 32221..33180 + 960 WP_012621507.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
HAPS_RS00135 33329..34150 + 822 WP_012621508.1 PHP domain-containing protein -
HAPS_RS00140 34257..34748 - 492 WP_005712683.1 acetolactate synthase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11257.23 Da        Isoelectric Point: 10.4221

>T23477 WP_012621505.1 NC_011852:30094-30378 [Glaesserella parasuis SH0165]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVAQGK
REHNDVYQKVQLRL

Download         Length: 285 bp

>T23477 NC_011852:30094-30378 [Glaesserella parasuis SH0165]
ATGAGCTATACCATTGAATTTATCCCATCAGCAGAAAAAGAGTTCCGTAAACTAAGCTTAGATTTAAGAAAACAATTTAT
CGAAAAACTTAAAGAAAGAGCTGAAAATCCGCGTGTAGAAAGTGCTAAACTTCGTGGAATGAAAGATTGTTATAAAATCA
AATTGCGTAATGCAGGCTATCGTTTGGTGTATCAAGTGATTGATGAACGTATTGTAATCAAAGTGGTTGCACAGGGAAAA
AGGGAGCACAACGACGTTTACCAAAAAGTACAATTACGTTTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9333.70 Da        Isoelectric Point: 4.4131

>AT23477 WP_010785924.1 NC_011852:29843-30097 [Glaesserella parasuis SH0165]
MPSVILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp

>AT23477 NC_011852:29843-30097 [Glaesserella parasuis SH0165]
ATGCCAAGTGTTATTTTAACCAATACCGTTGCGAGTATTACAGAACTAAAGACAAATCCAATGGCGACATTCAATGCGGC
AGGCGGTGAGGCAATTGCAATTTTAAACCGAAATGAACCCGCTTTTTATTGTGTACCACCGCATATTTATGAATATCTCA
TTGAGCTTGCTGATGATGCAGAATTAGCAAAATTAGTGGAAGAACGCCAACACGAAAAAAGCTACAAAGTGGATTTAGCG
GATTTATTAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B8F327

Antitoxin

Source ID Structure
AlphaFold DB A0A836Z1U9

References