Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1055015..1055635 Replicon chromosome
Accession NZ_CP091779
Organism Enterobacter mori strain ACYC.E9L

Toxin (Protein)


Gene name Hha Uniprot ID V3PUI7
Locus tag L6Y89_RS04985 Protein ID WP_010428174.1
Coordinates 1055015..1055233 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag L6Y89_RS04990 Protein ID WP_008499288.1
Coordinates 1055261..1055635 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6Y89_RS04955 (L6Y89_04955) 1051025..1051285 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
L6Y89_RS04960 (L6Y89_04960) 1051288..1051428 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
L6Y89_RS04965 (L6Y89_04965) 1051425..1052135 - 711 WP_089597997.1 GNAT family protein -
L6Y89_RS04970 (L6Y89_04970) 1052237..1053697 + 1461 WP_237846014.1 PLP-dependent aminotransferase family protein -
L6Y89_RS04975 (L6Y89_04975) 1053669..1054136 - 468 WP_237846017.1 YlaC family protein -
L6Y89_RS04980 (L6Y89_04980) 1054254..1054805 - 552 WP_010428173.1 maltose O-acetyltransferase -
L6Y89_RS04985 (L6Y89_04985) 1055015..1055233 - 219 WP_010428174.1 HHA domain-containing protein Toxin
L6Y89_RS04990 (L6Y89_04990) 1055261..1055635 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
L6Y89_RS04995 (L6Y89_04995) 1056145..1059291 - 3147 WP_089598001.1 multidrug efflux RND transporter permease subunit AcrB -
L6Y89_RS05000 (L6Y89_05000) 1059314..1060507 - 1194 WP_237846020.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8597.97 Da        Isoelectric Point: 8.9008

>T234767 WP_010428174.1 NZ_CP091779:c1055233-1055015 [Enterobacter mori]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T234767 NZ_LR134082:182695-182802 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT234767 WP_008499288.1 NZ_CP091779:c1055635-1055261 [Enterobacter mori]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT234767 NZ_LR134082:c182647-182581 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V3PUI7

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References