Detailed information of TA system TA234766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 488079..488595
• Replicon: chromosome
• Accession: NZ_CP091779
• Organism: Enterobacter mori strain ACYC.E9L

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L6Y89_RS02345
• Protein ID: WP_109082346.1
• Coordinates: 488311..488595 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V3EXX3
• Locus tag: L6Y89_RS02340
• Protein ID: WP_008501400.1
• Coordinates: 488079..488321 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6Y89_RS02325 (L6Y89_02325)	484079..484819	+	741	WP_237845415.1	KDGP aldolase family protein	-
L6Y89_RS02330 (L6Y89_02330)	484935..486071	+	1137	WP_237845417.1	lactonase family protein	-
L6Y89_RS02335 (L6Y89_02335)	486091..488001	+	1911	WP_237845419.1	PRD domain-containing protein	-
L6Y89_RS02340 (L6Y89_02340)	488079..488321	+	243	WP_008501400.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
L6Y89_RS02345 (L6Y89_02345)	488311..488595	+	285	WP_109082346.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L6Y89_RS02350 (L6Y89_02350)	488599..489063	-	465	WP_237845423.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
L6Y89_RS02355 (L6Y89_02355)	489204..491342	-	2139	WP_047646505.1	anaerobic ribonucleoside-triphosphate reductase	-
L6Y89_RS02360 (L6Y89_02360)	491711..492283	-	573	WP_237845426.1	fructose PTS transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10894.69 Da
• Isoelectric Point: 10.1988

>T234766 WP_109082346.1 NZ_CP091779:488311-488595 [Enterobacter mori]
MTYELAFDPRALKEWSKLGETVKDQFKKKLADVLVNPRVESARLHGLPDCYKIKLRSQGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T234766 NZ_LR134080:c4832778-4832467 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8972.37 Da
• Isoelectric Point: 5.0651

>AT234766 WP_008501400.1 NZ_CP091779:488079-488321 [Enterobacter mori]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT234766 NZ_LR134080:c4832466-4832176 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Antitoxin

• AlphaFold DB: V3EXX3