Detailed information of TA system TA023476

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-HTH_37
• Location: 4854347..4855010
• Replicon: chromosome
• Accession: NC_011830
• Organism: Desulfitobacterium hafniense DCB-2

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: Q24S02
• Locus tag: DHAF_RS22785
• Protein ID: WP_011461083.1
• Coordinates: 4854651..4855010 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: DHAF_RS22780
• Protein ID: WP_005815811.1
• Coordinates: 4854347..4854643 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DHAF_RS22755	4849523..4850290	-	768	WP_015945305.1	ABC transporter ATP-binding protein	-
DHAF_RS22760	4850461..4851129	-	669	WP_005815804.1	ATP-binding cassette domain-containing protein	-
DHAF_RS22765	4851129..4851821	-	693	WP_005815806.1	molybdate ABC transporter permease subunit	-
DHAF_RS22770	4851981..4852820	-	840	WP_015945306.1	molybdate ABC transporter substrate-binding protein	-
DHAF_RS22775	4853203..4854210	+	1008	WP_015945307.1	helix-turn-helix transcriptional regulator	-
DHAF_RS22780	4854347..4854643	-	297	WP_005815811.1	helix-turn-helix transcriptional regulator	Antitoxin
DHAF_RS22785	4854651..4855010	-	360	WP_011461083.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DHAF_RS22790	4855219..4856454	-	1236	WP_015945308.1	LL-diaminopimelate aminotransferase	-
DHAF_RS22795	4856845..4859346	-	2502	WP_015945309.1	diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (18-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (31-85)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 14026.20 Da
• Isoelectric Point: 9.5218

>T23476 WP_011461083.1 NC_011830:c4855010-4854651 [Desulfitobacterium hafniense DCB-2]
MFQIEFYNDAQGNSPIEDFLDKLDKKAATSKANRVRLKKIYEYLDILEKLGPIGEPYTKHLDGKIWELRPYSDRILFAGL
IDGKFILLHHFVKKTNKTPRREIEKALTNLEDYIQRAKE

Nucleotide

• Length: 360 bp

>T23476 NC_011830:c4855010-4854651 [Desulfitobacterium hafniense DCB-2]
ATGTTTCAAATTGAATTTTATAATGATGCTCAAGGCAATTCACCAATTGAAGATTTTTTAGATAAACTGGATAAGAAAGC
GGCAACCAGCAAGGCAAACCGAGTCCGGCTTAAAAAGATTTATGAGTATTTGGACATTCTGGAGAAACTAGGGCCAATCG
GCGAGCCCTATACAAAACATTTGGACGGGAAGATATGGGAACTTAGACCATATAGTGATAGAATTTTATTTGCAGGCTTG
ATAGACGGCAAATTTATTCTTCTTCATCATTTTGTTAAGAAAACCAATAAAACACCAAGACGGGAAATCGAAAAGGCACT
TACAAACTTAGAAGATTATATTCAAAGGGCAAAGGAGTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11105.85 Da
• Isoelectric Point: 8.4935

>AT23476 WP_005815811.1 NC_011830:c4854643-4854347 [Desulfitobacterium hafniense DCB-2]
MAKTWNDYKKNIKSLTAEEKAEIDLKVKIVSQIVEARKEKGLSQTELEAISGIKQTHIARLENNRNDPQLTTILKLLYPL
GMTLDVVPIVPFDTNQSQ

Nucleotide

• Length: 297 bp

>AT23476 NC_011830:c4854643-4854347 [Desulfitobacterium hafniense DCB-2]
ATGGCAAAAACCTGGAATGATTACAAAAAAAATATAAAATCCTTAACAGCAGAAGAAAAAGCTGAAATTGATTTGAAAGT
TAAAATCGTTAGCCAAATTGTAGAAGCCAGAAAAGAAAAAGGATTGAGTCAGACTGAACTGGAAGCAATCAGCGGAATTA
AGCAAACTCATATAGCCCGGCTTGAAAATAACCGCAATGACCCTCAGCTAACAACCATTTTAAAGCTGCTGTACCCATTG
GGAATGACACTGGATGTTGTCCCTATCGTCCCCTTCGACACAAACCAATCCCAATAA

Structures

Toxin

• AlphaFold DB: Q24S02