Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4401321..4402365 Replicon chromosome
Accession NZ_CP091773
Organism Escherichia coli strain SWYH.B349aT

Toxin (Protein)


Gene name panT Uniprot ID A0A829CP20
Locus tag L6V99_RS21600 Protein ID WP_000019186.1
Coordinates 4401321..4401869 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag L6V99_RS21605 Protein ID WP_000287252.1
Coordinates 4401892..4402365 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6V99_RS21565 (4396533) 4396533..4397084 - 552 WP_000515860.1 protein YmfL -
L6V99_RS21570 (4397128) 4397128..4397328 - 201 WP_000649477.1 YdaS family helix-turn-helix protein -
L6V99_RS21575 (4397419) 4397419..4398093 + 675 WP_000859462.1 LexA family transcriptional repressor -
L6V99_RS21580 (4398760) 4398760..4399122 + 363 WP_000135682.1 protein YfdP -
L6V99_RS21585 (4399188) 4399188..4400012 + 825 WP_001753751.1 DUF2303 family protein -
L6V99_RS21590 (4400199) 4400199..4400981 + 783 WP_000610754.1 hypothetical protein -
L6V99_RS21595 (4401018) 4401018..4401287 + 270 WP_001093912.1 pyocin activator PrtN family protein -
L6V99_RS21600 (4401321) 4401321..4401869 - 549 WP_000019186.1 hypothetical protein Toxin
L6V99_RS21605 (4401892) 4401892..4402365 - 474 WP_000287252.1 DUF4065 domain-containing protein Antitoxin
L6V99_RS21610 (4402670) 4402670..4402774 - 105 Protein_4228 tRNA-dihydrouridine synthase -
L6V99_RS21615 (4403137) 4403137..4404153 - 1017 WP_000912595.1 DUF2713 family protein -
L6V99_RS21620 (4404471) 4404471..4404986 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
L6V99_RS21625 (4405028) 4405028..4405237 - 210 WP_001030593.1 CsbD family protein -
L6V99_RS21630 (4405353) 4405353..4406678 - 1326 WP_001301116.1 MATE family efflux transporter DinF -
L6V99_RS21635 (4406751) 4406751..4407359 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4375985..4407359 31374


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20026.39 Da        Isoelectric Point: 4.4481

>T234756 WP_000019186.1 NZ_CP091773:c4401869-4401321 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKAPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

>T234756 NZ_LR134080:2831528-2831635 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT234756 WP_000287252.1 NZ_CP091773:c4402365-4401892 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT234756 NZ_LR134080:c2831481-2831415 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CP20

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References