Detailed information of TA system TA023475

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 3799249..3799792
• Replicon: chromosome
• Accession: NC_011830
• Organism: Desulfitobacterium hafniense DCB-2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B8FQD0
• Locus tag: DHAF_RS17830
• Protein ID: WP_005810841.1
• Coordinates: 3799520..3799792 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B8FQC9
• Locus tag: DHAF_RS17825
• Protein ID: WP_005810843.1
• Coordinates: 3799249..3799527 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DHAF_RS17800	3794609..3795853	-	1245	WP_015943229.1	IS4-like element ISDha2 family transposase	-
DHAF_RS17805	3796099..3796920	-	822	WP_015944671.1	hypothetical protein	-
DHAF_RS17810	3797160..3797600	-	441	WP_015944672.1	hypothetical protein	-
DHAF_RS17815	3797694..3798431	-	738	WP_015944673.1	DUF4367 domain-containing protein	-
DHAF_RS17820	3798424..3798968	-	545	Protein_3518	RNA polymerase sigma factor	-
DHAF_RS17825	3799249..3799527	+	279	WP_005810843.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DHAF_RS17830	3799520..3799792	+	273	WP_005810841.1	type II toxin-antitoxin system YafQ family toxin	Toxin
DHAF_RS17835	3799949..3800983	-	1035	WP_015944674.1	AI-2E family transporter	-
DHAF_RS17840	3801414..3801608	-	195	WP_005810836.1	hypothetical protein	-
DHAF_RS17845	3801605..3802099	-	495	WP_015944676.1	PRC-barrel domain-containing protein	-
DHAF_RS17850	3802251..3803363	-	1113	WP_015944677.1	tRNA 2-thiouridine(34) synthase MnmA	-
DHAF_RS17855	3803375..3803749	-	375	WP_015944678.1	Fe-S cluster assembly scaffold protein NifU	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3794609..3795853	1244

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-71)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10615.26 Da
• Isoelectric Point: 7.2400

>T23475 WP_005810841.1 NC_011830:3799520-3799792 [Desulfitobacterium hafniense DCB-2]
MYKIFPSTQFKKDLKLVLKRGYNMNLMDEVVTTLAQGRTLPDKYRDHALKGNYEGCRECHITPDWLLVYELTENELILYL
TRTGTHSDLF

Nucleotide

• Length: 273 bp

>T23475 NC_011830:3799520-3799792 [Desulfitobacterium hafniense DCB-2]
ATGTATAAAATCTTCCCTTCCACCCAATTCAAAAAGGATTTGAAGCTCGTCCTCAAGAGAGGATACAACATGAATCTGAT
GGATGAGGTTGTGACAACACTTGCACAAGGAAGAACGCTGCCTGACAAATATCGTGACCACGCCTTGAAGGGAAATTATG
AGGGATGCCGAGAATGCCACATCACACCGGACTGGCTCTTGGTTTATGAGCTTACGGAAAACGAACTGATTTTGTATTTA
ACCAGAACAGGAACGCACAGTGATTTATTCTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10598.21 Da
• Isoelectric Point: 4.7863

>AT23475 WP_005810843.1 NC_011830:3799249-3799527 [Desulfitobacterium hafniense DCB-2]
MAQTNINIRMDENLKQDFDRLCGELGLTMTTAFTIFAKTMVRQNGIPFPVSLDMPNEETLAAINEIQRMKQKPNKKLYSN
FSELLREVETDV

Nucleotide

• Length: 279 bp

>AT23475 NC_011830:3799249-3799527 [Desulfitobacterium hafniense DCB-2]
ATGGCGCAGACCAATATCAATATTCGTATGGATGAAAACCTGAAGCAAGATTTTGACAGACTATGTGGTGAATTAGGTCT
AACTATGACCACTGCGTTCACCATTTTTGCAAAAACCATGGTTCGGCAAAACGGAATACCCTTTCCTGTTTCGTTGGATA
TGCCCAACGAGGAAACACTGGCGGCGATCAACGAAATACAGCGCATGAAGCAGAAGCCGAATAAAAAACTTTACTCCAAC
TTCTCTGAGCTTCTACGCGAGGTGGAGACAGATGTATAA

Structures

Toxin

• AlphaFold DB: B8FQD0

Antitoxin

• AlphaFold DB: B8FQC9