Detailed information of TA system TA023474

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 3409795..3410371
• Replicon: chromosome
• Accession: NC_011830
• Organism: Desulfitobacterium hafniense DCB-2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B8G1F4
• Locus tag: DHAF_RS15915
• Protein ID: WP_015944457.1
• Coordinates: 3409795..3410094 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DHAF_RS15920
• Protein ID: WP_172641904.1
• Coordinates: 3410087..3410371 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DHAF_RS15880	3405332..3405934	-	603	WP_015944450.1	hypothetical protein	-
DHAF_RS15885	3406023..3406487	-	465	WP_015944451.1	hypothetical protein	-
DHAF_RS25570	3406698..3406805	-	108	Protein_3130	ATP-binding cassette domain-containing protein	-
DHAF_RS15895	3407465..3407893	-	429	WP_015944453.1	hypothetical protein	-
DHAF_RS15900	3407922..3408245	-	324	Protein_3132	sensor histidine kinase	-
DHAF_RS15905	3408226..3409206	-	981	WP_015944455.1	polyprenyl synthetase family protein	-
DHAF_RS15910	3409197..3409397	-	201	WP_015944456.1	hypothetical protein	-
DHAF_RS15915	3409795..3410094	-	300	WP_015944457.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
DHAF_RS15920	3410087..3410371	-	285	WP_172641904.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DHAF_RS15925	3410399..3410599	-	201	Protein_3137	type II toxin-antitoxin system RelE/ParE family toxin	-
DHAF_RS15930	3410589..3410855	-	267	WP_005812614.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
DHAF_RS15935	3411183..3412736	-	1554	WP_193345605.1	hypothetical protein	-
DHAF_RS15940	3412823..3413479	-	657	WP_015944461.1	hypothetical protein	-
DHAF_RS15945	3413533..3413730	-	198	WP_005812623.1	hypothetical protein	-
DHAF_RS15950	3413790..3413969	+	180	Protein_3142	type II toxin-antitoxin system RelB/DinJ family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-90)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11599.39 Da
• Isoelectric Point: 8.6988

>T23474 WP_015944457.1 NC_011830:c3410094-3409795 [Desulfitobacterium hafniense DCB-2]
MYEVKSTNRFKRDLKYIQRRGYDMRLLTAVIQTLASGEPLTEKHKDHALSGIWSKYRECHVTPDWLLIYKVEDDILVLTL
TRTGIHSDLFGQGNCRQCL

Nucleotide

• Length: 300 bp

>T23474 NC_011830:c3410094-3409795 [Desulfitobacterium hafniense DCB-2]
ATGTATGAAGTGAAGTCGACTAATCGCTTTAAGCGTGATCTGAAATATATCCAGCGCAGAGGCTATGATATGCGCCTTCT
TACGGCAGTCATTCAAACACTGGCTTCAGGAGAGCCTCTTACTGAAAAGCATAAGGATCATGCGTTGAGCGGCATTTGGT
CAAAGTATCGGGAGTGTCACGTCACACCGGACTGGTTGCTCATTTATAAGGTTGAAGATGACATACTCGTTTTGACCCTC
ACCCGTACCGGAATTCATAGCGACTTGTTCGGACAAGGCAACTGCAGACAATGCTTATGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10710.30 Da
• Isoelectric Point: 4.2584

>AT23474 WP_172641904.1 NC_011830:c3410371-3410087 [Desulfitobacterium hafniense DCB-2]
IMADTTNITIRMDVELKKQAEQLFSELGMNMTTAFTIFLRQAVRQQRIPFDIALENPNAETIAAMEEAERVSRDPSVKGY
TDIDQMMKELLADV

Nucleotide

• Length: 285 bp

>AT23474 NC_011830:c3410371-3410087 [Desulfitobacterium hafniense DCB-2]
ATTATGGCTGACACGACGAATATAACCATTCGTATGGATGTTGAATTAAAAAAACAGGCTGAGCAGCTTTTCTCTGAGCT
TGGAATGAACATGACGACAGCCTTCACTATTTTCCTGCGTCAGGCCGTGCGTCAGCAGAGAATTCCCTTTGATATTGCTC
TTGAGAATCCGAATGCCGAGACGATTGCCGCCATGGAAGAGGCTGAGCGCGTCAGCCGTGACCCTTCGGTTAAAGGCTAT
ACTGATATCGATCAGATGATGAAGGAGCTTTTGGCTGATGTATGA

Structures

Toxin

• AlphaFold DB: B8G1F4