Detailed information of TA system TA234735

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1092407..1093613
• Replicon: chromosome
• Accession: NZ_CP091770
• Organism: Helicobacter pylori strain K115

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: L6503_RS05185
• Protein ID: WP_237775424.1
• Coordinates: 1092407..1093186 (-)
• Length: 260 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: L6503_RS05190
• Protein ID: WP_024948607.1
• Coordinates: 1093176..1093613 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6503_RS05175 (L6503_05175)	1089746..1090906	+	1161	WP_237775422.1	aminotransferase class V-fold PLP-dependent enzyme	-
L6503_RS05180 (L6503_05180)	1090993..1092180	+	1188	WP_237775423.1	transcription termination factor NusA	-
L6503_RS05185 (L6503_05185)	1092407..1093186	-	780	WP_237775424.1	Frag1/DRAM/Sfk1 family protein	Toxin
L6503_RS05190 (L6503_05190)	1093176..1093613	-	438	WP_024948607.1	Panacea domain-containing protein	Antitoxin
L6503_RS05195 (L6503_05195)	1093837..1095466	-	1630	Protein_1009	RNA-directed DNA polymerase	-
L6503_RS05200 (L6503_05200)	1095477..1096031	-	555	WP_237775425.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 260 a.a.
• Molecular weight: 30588.86 Da
• Isoelectric Point: 9.5957

>T234735 WP_237775424.1 NZ_CP091770:c1093186-1092407 [Helicobacter pylori]
MEIKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDISIRLDNLNKNYKKLSEELNKQQTQYITILGIFASIVLTFVG
GLAFSTSVLSNIDKANAYRLVFIMAFIALFFGNILYLLFSFLSKISLSKEERDKQENFFKKPIFWFNLMVIILFVIGFVG
ERIDRQYKAQISKDFKRPR

Nucleotide

• Length: 780 bp

>T234735 NZ_LR134079:3061968-3062075 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17317.36 Da
• Isoelectric Point: 5.3873

>AT234735 WP_024948607.1 NZ_CP091770:c1093613-1093176 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVSREVYYEYRNYGANSIDKPKEETL
SQDLREDELETINRSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT234735 NZ_LR134079:c3061915-3061854 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT