Detailed information of TA system TA234733

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 523417..524041
• Replicon: chromosome
• Accession: NZ_CP091770
• Organism: Helicobacter pylori strain K115

Toxin (Protein)

• Gene name: relE
• Uniprot ID: E6S2G8
• Locus tag: L6503_RS02405
• Protein ID: WP_000916177.1
• Coordinates: 523417..523683 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: L6503_RS02410
• Protein ID: WP_237775960.1
• Coordinates: 523664..524041 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6503_RS02385 (L6503_02385)	520064..520831	-	768	WP_237775958.1	ABC transporter ATP-binding protein	-
L6503_RS02390 (L6503_02390)	520831..521811	-	981	WP_000921438.1	iron ABC transporter permease	-
L6503_RS02395 (L6503_02395)	521804..522646	-	843	WP_237775959.1	SDR family oxidoreductase	-
L6503_RS02400 (L6503_02400)	522786..523310	+	525	WP_001135602.1	acyl-CoA thioesterase	-
L6503_RS02405 (L6503_02405)	523417..523683	-	267	WP_000916177.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
L6503_RS02410 (L6503_02410)	523664..524041	-	378	WP_237775960.1	hypothetical protein	Antitoxin
L6503_RS02415 (L6503_02415)	524661..526886	-	2226	WP_237775961.1	Hop family adhesin BabA	-
L6503_RS02430 (L6503_02430)	527319..527891	+	573	WP_237776098.1	helicase DnaB modulator	-
L6503_RS02435 (L6503_02435)	527842..528954	-	1113	WP_237775962.1	hydrogenase formation protein HypD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10331.19 Da
• Isoelectric Point: 9.6561

>T234733 WP_000916177.1 NZ_CP091770:c523683-523417 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVRDDELILVR
LGSHSELF

Nucleotide

• Length: 267 bp

>T234733 NZ_LR134079:c2824690-2824403 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14648.56 Da
• Isoelectric Point: 5.9596

>AT234733 WP_237775960.1 NZ_CP091770:c524041-523664 [Helicobacter pylori]
MPNSSTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GHKIPNLETQQAMIDALNKETDLIVEDFSSYSDERKRALGVETQP

Nucleotide

• Length: 378 bp

>AT234733 NZ_LR134079:c2824929-2824690 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: A0A402E178