Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2316655..2317630 Replicon chromosome
Accession NZ_CP091767
Organism Bacillus anthracis strain ChBA30D

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag L6178_RS12095 Protein ID WP_002036394.1
Coordinates 2316655..2317392 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag L6178_RS12100 Protein ID WP_000588712.1
Coordinates 2317505..2317630 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6178_RS12075 (L6178_12075) 2312383..2313165 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
L6178_RS12080 (L6178_12080) 2313287..2314972 - 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
L6178_RS12085 (L6178_12085) 2315079..2315561 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
L6178_RS12090 (L6178_12090) 2315729..2316466 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
L6178_RS12095 (L6178_12095) 2316655..2317392 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
L6178_RS12100 (L6178_12100) 2317505..2317630 + 126 WP_000588712.1 hypothetical protein Antitoxin
L6178_RS12105 (L6178_12105) 2317707..2317883 + 177 WP_000852614.1 hypothetical protein -
L6178_RS12110 (L6178_12110) 2317920..2318201 - 282 WP_001041555.1 hypothetical protein -
L6178_RS12115 (L6178_12115) 2318478..2318714 - 237 WP_001021689.1 hypothetical protein -
L6178_RS27940 2318851..2318976 + 126 WP_000694311.1 hypothetical protein -
L6178_RS12120 (L6178_12120) 2319053..2319229 + 177 WP_000808045.1 stage II sporulation protein SB -
L6178_RS12125 (L6178_12125) 2319373..2320842 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
L6178_RS12130 (L6178_12130) 2321406..2321876 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T234732 WP_002036394.1 NZ_CP091767:2316655-2317392 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T234732 NZ_LR134079:c2749754-2748432 [Escherichia coli]
ATGCCCAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACTTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCTCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGGGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGAATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGGTATG
ATTTTATGAAATTCCAGGTCTTTCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGTACTGGATAACGTGAAGACTTCATTACCAACAGATTTTCCAGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT234732 WP_000588712.1 NZ_CP091767:2317505-2317630 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT234732 NZ_LR134079:c2750020-2749754 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGCATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAAAAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References