Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-DinJ
Location 2175591..2176121 Replicon chromosome
Accession NC_011830
Organism Desulfitobacterium hafniense DCB-2

Toxin (Protein)


Gene name yoeB Uniprot ID B8FRE8
Locus tag DHAF_RS10075 Protein ID WP_015943793.1
Coordinates 2175858..2176121 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B8FRE7
Locus tag DHAF_RS10070 Protein ID WP_015943792.1
Coordinates 2175591..2175854 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DHAF_RS10035 2171098..2171556 + 459 WP_005813957.1 MarR family transcriptional regulator -
DHAF_RS10040 2171669..2172232 + 564 WP_011459439.1 nitroreductase -
DHAF_RS10045 2172486..2172803 + 318 WP_015943786.1 hypothetical protein -
DHAF_RS10050 2172944..2173423 + 480 WP_015943787.1 GNAT family N-acetyltransferase -
DHAF_RS10055 2173721..2174029 - 309 WP_015943789.1 helix-turn-helix domain-containing protein -
DHAF_RS10060 2174170..2174394 + 225 WP_015943790.1 stage 0 sporulation protein A, two-component response regualtor -
DHAF_RS10065 2174462..2175361 + 900 WP_015943791.1 hypothetical protein -
DHAF_RS10070 2175591..2175854 + 264 WP_015943792.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DHAF_RS10075 2175858..2176121 + 264 WP_015943793.1 Txe/YoeB family addiction module toxin Toxin
DHAF_RS10080 2176270..2176677 + 408 WP_015943794.1 type II toxin-antitoxin system HicB family antitoxin -
DHAF_RS10085 2177190..2178038 + 849 WP_041272074.1 MerR family transcriptional regulator -
DHAF_RS10090 2178152..2178637 + 486 WP_015943796.1 isoprenylcysteine carboxylmethyltransferase family protein -
DHAF_RS10095 2178688..2179011 + 324 WP_193345601.1 DUF1992 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-56)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10333.76 Da        Isoelectric Point: 9.7311

>T23473 WP_015943793.1 NC_011830:2175858-2176121 [Desulfitobacterium hafniense DCB-2]
MKKLWTDQAWADYLYWQSQDKKTLKRVNQLLLDIERNGYDGIGKPEQLRGDLGGWWSRRIDNTNRLVYRMTDGIIVIASC
RTHYGDK

Download         Length: 264 bp

>T23473 NC_011830:2175858-2176121 [Desulfitobacterium hafniense DCB-2]
ATGAAAAAGTTATGGACTGACCAAGCCTGGGCAGACTACCTATACTGGCAAAGCCAAGATAAAAAAACGCTGAAAAGAGT
AAACCAACTTTTACTGGATATTGAGCGCAATGGTTATGATGGAATTGGTAAGCCGGAACAGTTGCGTGGTGATTTAGGTG
GGTGGTGGTCCCGCCGTATCGATAACACGAACCGGCTTGTCTATCGTATGACTGATGGGATAATCGTTATAGCAAGCTGT
CGTACGCATTACGGTGATAAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9850.15 Da        Isoelectric Point: 4.5026

>AT23473 WP_015943792.1 NC_011830:2175591-2175854 [Desulfitobacterium hafniense DCB-2]
MAETTNLNIRIDKELKEQAEVFFNELGLNMTTAFNIFVRQSLRQGGIPFDITLNTDGFYNPANMKMLRQSIQDANEGKLT
AHDLLGD

Download         Length: 264 bp

>AT23473 NC_011830:2175591-2175854 [Desulfitobacterium hafniense DCB-2]
ATGGCTGAAACGACCAACTTGAATATCAGGATTGATAAAGAGCTGAAAGAGCAGGCTGAAGTGTTTTTCAATGAGTTAGG
CCTGAATATGACAACCGCGTTTAATATTTTTGTGCGGCAATCCCTTCGGCAAGGAGGAATACCTTTTGATATTACGTTGA
ATACGGATGGCTTTTATAATCCAGCGAATATGAAAATGCTACGACAATCCATTCAGGATGCCAACGAAGGTAAGCTGACC
GCTCATGATTTACTTGGTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B8FRE8

Antitoxin

Source ID Structure
AlphaFold DB A0A1M7SFP7

References