Detailed information of TA system TA234719

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4286998..4287812
• Replicon: chromosome
• Accession: NZ_CP091756
• Organism: Escherichia coli strain LC-1302-2020

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: L6507_RS20800
• Protein ID: WP_001054376.1
• Coordinates: 4286998..4287255 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: L6507_RS20805
• Protein ID: WP_001309181.1
• Coordinates: 4287267..4287812 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6507_RS20775 (4282286)	4282286..4283392	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
L6507_RS20780 (4283457)	4283457..4284437	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
L6507_RS20785 (4284547)	4284547..4284752	+	206	Protein_4062	HNH endonuclease	-
L6507_RS20790 (4285020)	4285020..4286260	-	1241	Protein_4063	helicase YjhR	-
L6507_RS20795 (4286376)	4286376..4286507	+	132	WP_001309182.1	hypothetical protein	-
L6507_RS20800 (4286998)	4286998..4287255	+	258	WP_001054376.1	YjhX family toxin	Toxin
L6507_RS20805 (4287267)	4287267..4287812	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
L6507_RS20810 (4287868)	4287868..4288614	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
L6507_RS20815 (4288783)	4288783..4289001	+	219	Protein_4068	hypothetical protein	-
L6507_RS20820 (4289039)	4289039..4289155	+	117	Protein_4069	VOC family protein	-
L6507_RS20825 (4289400)	4289400..4290521	+	1122	WP_000010829.1	M42 family metallopeptidase	-
L6507_RS20830 (4290518)	4290518..4290796	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
L6507_RS20835 (4290808)	4290808..4292121	+	1314	WP_000460843.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	4275433..4303502	28069

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T234719 WP_001054376.1 NZ_CP091756:4286998-4287255 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T234719 NZ_LR134075:c4133384-4133211 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT234719 WP_001309181.1 NZ_CP091756:4287267-4287812 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT234719 NZ_LR134075:c4133708-4133412 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8