Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2591309..2591947 Replicon chromosome
Accession NZ_CP091756
Organism Escherichia coli strain LC-1302-2020

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag L6507_RS12520 Protein ID WP_000813794.1
Coordinates 2591771..2591947 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L6507_RS12515 Protein ID WP_001270286.1
Coordinates 2591309..2591725 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6507_RS12495 (2586461) 2586461..2587402 - 942 WP_001251304.1 ABC transporter permease -
L6507_RS12500 (2587403) 2587403..2588416 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
L6507_RS12505 (2588434) 2588434..2589579 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
L6507_RS12510 (2589824) 2589824..2591230 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
L6507_RS12515 (2591309) 2591309..2591725 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
L6507_RS12520 (2591771) 2591771..2591947 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
L6507_RS12525 (2592169) 2592169..2592399 + 231 WP_000494244.1 YncJ family protein -
L6507_RS12530 (2592491) 2592491..2594452 - 1962 WP_032342722.1 23S rRNA 5-hydroxycytidine C2501 synthase -
L6507_RS12535 (2594525) 2594525..2595061 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
L6507_RS12540 (2595153) 2595153..2596328 + 1176 WP_021572812.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T234715 WP_000813794.1 NZ_CP091756:c2591947-2591771 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T234715 NZ_LR134075:c3559757-3559359 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT234715 WP_001270286.1 NZ_CP091756:c2591725-2591309 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT234715 NZ_LR134075:c3560053-3559760 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References