Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 1455366..1455991 Replicon chromosome
Accession NC_011830
Organism Desulfitobacterium hafniense DCB-2

Toxin (Protein)


Gene name pemK Uniprot ID Q24Q87
Locus tag DHAF_RS06755 Protein ID WP_005817423.1
Coordinates 1455641..1455991 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q24Q86
Locus tag DHAF_RS06750 Protein ID WP_011461523.1
Coordinates 1455366..1455644 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DHAF_RS06730 1450995..1451525 - 531 WP_015943371.1 gamma carbonic anhydrase family protein -
DHAF_RS06735 1451818..1452834 + 1017 WP_005817430.1 2-hydroxyacid dehydrogenase family protein -
DHAF_RS06740 1452970..1454369 + 1400 Protein_1326 DUF1727 domain-containing protein -
DHAF_RS06745 1454372..1455136 + 765 WP_005817427.1 glutamine amidotransferase -
DHAF_RS06750 1455366..1455644 + 279 WP_011461523.1 ribbon-helix-helix protein, CopG family Antitoxin
DHAF_RS06755 1455641..1455991 + 351 WP_005817423.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DHAF_RS06760 1456188..1456910 + 723 WP_015943373.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
DHAF_RS06765 1457199..1459334 + 2136 WP_015943374.1 molybdopterin-dependent oxidoreductase -
DHAF_RS06770 1459597..1459905 + 309 WP_005817412.1 DUF2325 domain-containing protein -
DHAF_RS06775 1459963..1460163 + 201 WP_011461520.1 YezD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-39)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12824.86 Da        Isoelectric Point: 5.8944

>T23471 WP_005817423.1 NC_011830:1455641-1455991 [Desulfitobacterium hafniense DCB-2]
MIIKRGEIYYAELNPVVGSEQGGTRPVLVIQNDIGNQFSPTTIIAAITSQIAKAKLPTHVEVRAKRSGLERDSVILTEQI
RTIDKSRLKEKVAVLDEEVMLRVDQAIEISLGLTDI

Download         Length: 351 bp

>T23471 NC_011830:1455641-1455991 [Desulfitobacterium hafniense DCB-2]
ATGATTATAAAACGCGGGGAAATCTACTATGCTGAACTCAACCCCGTCGTCGGATCCGAGCAAGGCGGTACCCGCCCTGT
GTTGGTGATCCAAAATGATATCGGAAATCAGTTTAGTCCGACGACTATTATAGCTGCGATTACATCTCAGATTGCTAAAG
CAAAGCTGCCGACTCATGTGGAGGTGCGGGCCAAGCGCAGTGGTTTGGAACGGGATTCGGTCATTTTGACGGAACAGATC
CGAACGATTGACAAAAGCCGCCTCAAGGAGAAGGTCGCCGTTCTTGATGAAGAAGTGATGCTGAGGGTGGATCAAGCGAT
TGAAATCAGTTTAGGACTGACTGATATTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10818.27 Da        Isoelectric Point: 4.6550

>AT23471 WP_011461523.1 NC_011830:1455366-1455644 [Desulfitobacterium hafniense DCB-2]
VAESKRIMISLPENLLAEVDDVVTLENRNRSEFIREAINSVLHERRKRGIREQMRKGYEEMAQLNLAIARELFLAEEEVQ
VVYEDSNVECQR

Download         Length: 279 bp

>AT23471 NC_011830:1455366-1455644 [Desulfitobacterium hafniense DCB-2]
GTGGCAGAGAGTAAGCGGATAATGATTAGTTTGCCGGAGAATTTGCTCGCGGAAGTGGATGATGTCGTTACGCTTGAGAA
TAGAAATCGTAGCGAATTTATACGTGAAGCAATCAACAGTGTTCTTCATGAACGCCGGAAACGGGGAATCCGCGAACAGA
TGCGTAAAGGTTATGAGGAAATGGCTCAATTGAACTTAGCCATTGCCAGAGAGCTGTTCCTTGCTGAGGAAGAGGTCCAG
GTGGTTTATGAAGATTCTAATGTGGAGTGTCAGAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M7T493

Antitoxin

Source ID Structure
AlphaFold DB A0A1M7T474

References