Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2382911..2383886 Replicon chromosome
Accession NC_011773
Organism Bacillus cereus AH820

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag BCAH820_RS12610 Protein ID WP_002036394.1
Coordinates 2382911..2383648 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag BCAH820_RS12615 Protein ID WP_000588712.1
Coordinates 2383761..2383886 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCAH820_RS12585 2378443..2378850 + 408 WP_000072500.1 VOC family protein -
BCAH820_RS12590 2379111..2379421 + 311 Protein_2388 hypothetical protein -
BCAH820_RS12595 2379543..2381228 - 1686 WP_041185067.1 alpha-keto acid decarboxylase family protein -
BCAH820_RS12600 2381335..2381817 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
BCAH820_RS12605 2381985..2382722 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BCAH820_RS12610 2382911..2383648 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BCAH820_RS12615 2383761..2383886 + 126 WP_000588712.1 hypothetical protein Antitoxin
BCAH820_RS31385 2383963..2384139 + 177 WP_000808045.1 hypothetical protein -
BCAH820_RS12625 2384283..2385752 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
BCAH820_RS12630 2385987..2386457 - 471 WP_000670597.1 DUF5065 family protein -
BCAH820_RS12635 2386634..2387254 + 621 WP_002036390.1 SGNH/GDSL hydrolase family protein -
BCAH820_RS12640 2387477..2388010 + 534 WP_000438322.1 sigma-70 family RNA polymerase sigma factor -
BCAH820_RS12645 2388000..2388827 + 828 WP_001060391.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T23470 WP_002036394.1 NC_011773:2382911-2383648 [Bacillus cereus AH820]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T23470 NC_011773:2382911-2383648 [Bacillus cereus AH820]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT23470 WP_000588712.1 NC_011773:2383761-2383886 [Bacillus cereus AH820]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT23470 NC_011773:2383761-2383886 [Bacillus cereus AH820]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References