Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5610803..5611413 Replicon chromosome
Accession NZ_CP091752
Organism Klebsiella grimontii strain LC-1303-2020

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L6506_RS26270 Protein ID WP_098363641.1
Coordinates 5610803..5611177 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L6506_RS26275 Protein ID WP_077253475.1
Coordinates 5611174..5611413 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6506_RS26255 (L6506_26255) 5607958..5608860 + 903 WP_004122548.1 formate dehydrogenase subunit beta -
L6506_RS26260 (L6506_26260) 5608857..5609492 + 636 WP_004132860.1 formate dehydrogenase cytochrome b556 subunit -
L6506_RS26265 (L6506_26265) 5609836..5610765 + 930 WP_004132861.1 formate dehydrogenase accessory protein FdhE -
L6506_RS26270 (L6506_26270) 5610803..5611177 - 375 WP_098363641.1 type II toxin-antitoxin system VapC family toxin Toxin
L6506_RS26275 (L6506_26275) 5611174..5611413 - 240 WP_077253475.1 CopG family transcriptional regulator Antitoxin
L6506_RS26280 (L6506_26280) 5611619..5612536 + 918 WP_024360706.1 alpha/beta hydrolase -
L6506_RS26285 (L6506_26285) 5612554..5613495 - 942 WP_004127112.1 fatty acid biosynthesis protein FabY -
L6506_RS26290 (L6506_26290) 5613540..5613977 - 438 WP_004132870.1 D-aminoacyl-tRNA deacylase -
L6506_RS26295 (L6506_26295) 5613974..5614834 - 861 WP_004127107.1 virulence factor BrkB family protein -
L6506_RS26300 (L6506_26300) 5614828..5615427 - 600 WP_024360709.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14081.36 Da        Isoelectric Point: 8.4571

>T234696 WP_098363641.1 NZ_CP091752:c5611177-5610803 [Klebsiella grimontii]
MIKGPALFDTNILIDLFSGRVEAKQVLEAYPPQNAISLITWTEVMVGAKKYHQEHRTRIALSAFNIIDISQDIAERSVNL
RKEYGMKLPDAIILATAQIHRYELVTRNTKDFFGIPGVITPYHL

Download         Length: 375 bp

>T234696 NZ_LR134031:4215952-4216209 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9293.49 Da        Isoelectric Point: 4.3142

>AT234696 WP_077253475.1 NZ_CP091752:c5611413-5611174 [Klebsiella grimontii]
MMTGTNMGRILLDLSDDVIKRLEDLKQQRNLPRAELLREAVEQYLERQADTTISNALGIWQGCEEDGVEFERKLREEWQ

Download         Length: 240 bp

>AT234696 NZ_LR134031:4216221-4216766 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCGGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCTTTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References