Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 5031023..5031713 Replicon chromosome
Accession NZ_CP091752
Organism Klebsiella grimontii strain LC-1303-2020

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag L6506_RS23555 Protein ID WP_041165267.1
Coordinates 5031023..5031364 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag L6506_RS23560 Protein ID WP_224253094.1
Coordinates 5031387..5031713 (-) Length 109 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6506_RS23530 (L6506_23530) 5026753..5027076 + 324 WP_154063373.1 endoribonuclease SymE -
L6506_RS23535 (L6506_23535) 5027223..5027657 + 435 WP_049113956.1 VOC family protein -
L6506_RS23540 (L6506_23540) 5027823..5028566 + 744 WP_224253091.1 hypothetical protein -
L6506_RS23545 (L6506_23545) 5028876..5029871 - 996 WP_224253092.1 hypothetical protein -
L6506_RS23550 (L6506_23550) 5030075..5030908 - 834 WP_224253093.1 DUF4942 domain-containing protein -
L6506_RS23555 (L6506_23555) 5031023..5031364 - 342 WP_041165267.1 TA system toxin CbtA family protein Toxin
L6506_RS23560 (L6506_23560) 5031387..5031713 - 327 WP_224253094.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L6506_RS23565 (L6506_23565) 5031727..5032203 - 477 WP_224253095.1 DNA repair protein RadC -
L6506_RS23570 (L6506_23570) 5032214..5032660 - 447 WP_014227715.1 antirestriction protein -
L6506_RS23575 (L6506_23575) 5032884..5033573 - 690 WP_041165265.1 hypothetical protein -
L6506_RS23580 (L6506_23580) 5034137..5035027 - 891 WP_014227713.1 YfjP family GTPase -
L6506_RS23585 (L6506_23585) 5035110..5036198 - 1089 WP_224253096.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5026753..5055119 28366


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-108)

Antitoxin

(8-106)


Sequences


Toxin        


Download         Length: 114 a.a.        Molecular weight: 12768.64 Da        Isoelectric Point: 7.9093

>T234695 WP_041165267.1 NZ_CP091752:c5031364-5031023 [Klebsiella grimontii]
MKTLPATTQRAAKPCPSPVTVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELIRIDRRGF
NCQEQSPYLGAADILRARQATGLLRQSHHPSIR

Download         Length: 342 bp

>T234695 NZ_LR134031:4178765-4179106 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCACTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACTGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTCGCCTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12310.07 Da        Isoelectric Point: 6.9563

>AT234695 WP_224253094.1 NZ_CP091752:c5031713-5031387 [Klebsiella grimontii]
MPLTDGIQWGLKRSFTPNFGARLVQEGNRLHNLADRANITGKFVDVECQKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPIQR

Download         Length: 327 bp

>AT234695 NZ_LR134031:c4178770-4178694 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References