Detailed information of TA system TA234694

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4543145..4543964
• Replicon: chromosome
• Accession: NZ_CP091752
• Organism: Klebsiella grimontii strain LC-1303-2020

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A9E1D5M6
• Locus tag: L6506_RS21310
• Protein ID: WP_004132607.1
• Coordinates: 4543707..4543964 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A9E1DGJ5
• Locus tag: L6506_RS21305
• Protein ID: WP_004132606.1
• Coordinates: 4543145..4543696 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6506_RS21275 (L6506_21275)	4538345..4538899	-	555	WP_224232944.1	fimbrial protein	-
L6506_RS21280 (L6506_21280)	4540144..4540365	+	222	WP_098067470.1	LuxR C-terminal-related transcriptional regulator	-
L6506_RS21285 (L6506_21285)	4541278..4541400	-	123	Protein_4186	VapC toxin family PIN domain ribonuclease	-
L6506_RS21290 (L6506_21290)	4541397..4541471	-	75	Protein_4187	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
L6506_RS21295 (L6506_21295)	4541499..4542245	-	747	WP_224238150.1	class I SAM-dependent methyltransferase	-
L6506_RS21300 (L6506_21300)	4542675..4543031	-	357	Protein_4189	class I SAM-dependent methyltransferase	-
L6506_RS21305 (L6506_21305)	4543145..4543696	-	552	WP_004132606.1	N-acetyltransferase	Antitoxin
L6506_RS21310 (L6506_21310)	4543707..4543964	-	258	WP_004132607.1	YjhX family toxin	Toxin
L6506_RS21315 (L6506_21315)	4544548..4545732	+	1185	WP_241449567.1	mannonate dehydratase	-
L6506_RS21320 (L6506_21320)	4545809..4547284	+	1476	WP_241449568.1	fructuronate reductase	-
L6506_RS21325 (L6506_21325)	4547421..4548197	+	777	WP_024359123.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (34-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.04 Da
• Isoelectric Point: 11.1381

>T234694 WP_004132607.1 NZ_CP091752:c4543964-4543707 [Klebsiella grimontii]
MNLSRQEQRTLHVLAKGGRIAHVRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T234694 NZ_LR134031:4052749-4052901 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19990.89 Da
• Isoelectric Point: 7.2343

>AT234694 WP_004132606.1 NZ_CP091752:c4543696-4543145 [Klebsiella grimontii]
MTNHSFTFHVASEGDTNDILHVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGKAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGGLIRHGIEQLKAMGSQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEALKACWMLQPLSS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT234694 NZ_LR134031:c4052700-4052643 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA