Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 4531508..4532151 | Replicon | chromosome |
| Accession | NZ_CP091752 | ||
| Organism | Klebsiella grimontii strain LC-1303-2020 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | - |
| Locus tag | L6506_RS21245 | Protein ID | WP_154916276.1 |
| Coordinates | 4531508..4531924 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | - |
| Locus tag | L6506_RS21250 | Protein ID | WP_098067465.1 |
| Coordinates | 4531921..4532151 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L6506_RS21225 (L6506_21225) | 4527741..4529138 | + | 1398 | WP_004132593.1 | MFS transporter | - |
| L6506_RS21230 (L6506_21230) | 4529262..4530602 | + | 1341 | WP_049085654.1 | carbohydrate porin | - |
| L6506_RS21235 (L6506_21235) | 4530740..4530940 | - | 201 | WP_241449564.1 | hypothetical protein | - |
| L6506_RS21240 (L6506_21240) | 4531221..4531520 | - | 300 | WP_241449565.1 | hypothetical protein | - |
| L6506_RS21245 (L6506_21245) | 4531508..4531924 | - | 417 | WP_154916276.1 | PIN domain-containing protein | Toxin |
| L6506_RS21250 (L6506_21250) | 4531921..4532151 | - | 231 | WP_098067465.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| L6506_RS21255 (L6506_21255) | 4532405..4533043 | + | 639 | WP_154916275.1 | hypothetical protein | - |
| L6506_RS21260 (L6506_21260) | 4533586..4534878 | - | 1293 | WP_098067467.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15088.63 Da Isoelectric Point: 7.2457
>T234693 WP_154916276.1 NZ_CP091752:c4531924-4531508 [Klebsiella grimontii]
MKKTWMLDTNICSFIMREQPESVLKRLEQAMLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDALCARLDAVLPLEHS
AVDATTDIKVALRLVGTPIGPNDTAIAGHAIAAGAILVTNNVREFERVPGLILEDWVK
MKKTWMLDTNICSFIMREQPESVLKRLEQAMLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDALCARLDAVLPLEHS
AVDATTDIKVALRLVGTPIGPNDTAIAGHAIAAGAILVTNNVREFERVPGLILEDWVK
Download Length: 417 bp
>T234693 NZ_LR134031:c4015095-4014973 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTGTTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTTGA
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTGTTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8669.73 Da Isoelectric Point: 4.6412
>AT234693 WP_098067465.1 NZ_CP091752:c4532151-4531921 [Klebsiella grimontii]
MHTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGNSIILRPVRPTWSSLASLEKADADFLKEREDVVSDEGRFEP
MHTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGNSIILRPVRPTWSSLASLEKADADFLKEREDVVSDEGRFEP
Download Length: 231 bp
>AT234693 NZ_LR134031:c4015331-4015098 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|