Detailed information of TA system TA234682

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 879341..880049
• Replicon: chromosome
• Accession: NZ_CP091752
• Organism: Klebsiella grimontii strain LC-1303-2020

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: L6506_RS04315
• Protein ID: WP_098067227.1
• Coordinates: 879726..880049 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: L6506_RS04310
• Protein ID: WP_098067228.1
• Coordinates: 879341..879691 (+)
• Length: 117 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6506_RS04280 (L6506_04280)	874519..875670	-	1152	WP_141522397.1	hypothetical protein	-
L6506_RS04285 (L6506_04285)	875768..876661	+	894	WP_098067233.1	50S ribosome-binding GTPase	-
L6506_RS04290 (L6506_04290)	876946..877623	+	678	WP_098067232.1	hypothetical protein	-
L6506_RS04295 (L6506_04295)	877719..878540	+	822	WP_176519000.1	DUF932 domain-containing protein	-
L6506_RS04300 (L6506_04300)	878611..879084	+	474	WP_098067230.1	DNA repair protein RadC	-
L6506_RS04305 (L6506_04305)	879099..879320	+	222	WP_098067229.1	DUF987 domain-containing protein	-
L6506_RS04310 (L6506_04310)	879341..879691	+	351	WP_098067228.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
L6506_RS04315 (L6506_04315)	879726..880049	+	324	WP_098067227.1	TA system toxin CbtA family protein	Toxin
L6506_RS04320 (L6506_04320)	880415..880765	+	351	WP_004134443.1	transcriptional regulator	-
L6506_RS04325 (L6506_04325)	880818..882110	+	1293	WP_241449751.1	arsenic transporter	-
L6506_RS04330 (L6506_04330)	882120..882545	+	426	WP_004134449.1	glutaredoxin-dependent arsenate reductase	-
L6506_RS04335 (L6506_04335)	882738..882896	+	159	WP_004134456.1	AAA family ATPase	-
L6506_RS04340 (L6506_04340)	882938..884587	-	1650	WP_024358595.1	OFA family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-106)

Antitoxin

• Antitoxin CbeA (15-115)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12211.05 Da
• Isoelectric Point: 6.4617

>T234682 WP_098067227.1 NZ_CP091752:879726-880049 [Klebsiella grimontii]
MNTLPAINQRAVQPYPSPVVVWQMLLARLLEQHYGLTLNDTPFSDEAVIKGHIEAGITLVDAVNSLVEKYELVRVDQRGF
SWQEQAPYLTIVDIMRARRYLGITNRS

Nucleotide

• Length: 324 bp

>T234682 NZ_LR134031:953761-954168 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 117 a.a.
• Molecular weight: 12916.67 Da
• Isoelectric Point: 5.5068

>AT234682 WP_098067228.1 NZ_CP091752:879341-879691 [Klebsiella grimontii]
MSNKTLTANDDTAEPWWGLSRNVIPCFGARMVQEGNRLHYLADRASITGQFNEADLLHLDQAFPVLLKQVELMLTSGELN
PRHQHCVTLYAKGLTCEADTLGSCGYVYIAIYPTQS

Nucleotide

• Length: 351 bp

>AT234682 NZ_LR134031:953514-953780 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA