23468

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2289755..2290733 Replicon chromosome
Accession NC_011772
Organism Bacillus cereus G9842

Toxin (Protein)


Gene name spoIISA Uniprot ID B7IX38
Locus tag BCG9842_RS11545 Protein ID WP_000624981.1
Coordinates 2289755..2290492 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID B7IX39
Locus tag BCG9842_RS11550 Protein ID WP_000237817.1
Coordinates 2290605..2290733 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCG9842_RS11520 2285346..2285753 + 408 WP_000072495.1 VOC family protein -
BCG9842_RS11525 2286098..2286880 + 783 WP_000381782.1 class I SAM-dependent methyltransferase -
BCG9842_RS11530 2287034..2287879 - 846 Protein_2228 alpha-keto acid decarboxylase family protein -
BCG9842_RS29640 2287855..2288023 - 169 Protein_2229 hypothetical protein -
BCG9842_RS11535 2288131..2288613 + 483 WP_000191905.1 MarR family winged helix-turn-helix transcriptional regulator -
BCG9842_RS11540 2288779..2289516 + 738 WP_000594159.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BCG9842_RS11545 2289755..2290492 + 738 WP_000624981.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BCG9842_RS11550 2290605..2290733 + 129 WP_000237817.1 hypothetical protein Antitoxin
BCG9842_RS11555 2290806..2290982 + 177 WP_000852629.1 stage II sporulation protein SB -
BCG9842_RS11560 2291001..2291390 - 390 WP_000712655.1 YxeA family protein -
BCG9842_RS11565 2291602..2293071 + 1470 WP_000287541.1 beta-Ala-His dipeptidase -
BCG9842_RS11570 2293384..2294193 + 810 WP_000678376.1 C39 family peptidase -
BCG9842_RS11575 2294219..2294824 + 606 WP_000527414.1 hypothetical protein -
BCG9842_RS11580 2294965..2295216 - 252 WP_000821942.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28335.09 Da        Isoelectric Point: 8.2998

>T23468 WP_000624981.1 NC_011772:2289755-2290492 [Bacillus cereus G9842]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T23468 NC_011772:2289755-2290492 [Bacillus cereus G9842]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACCACAATTATTCAAAATGTTAATCCAGCAGTTTTCGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAGAGCTTAAATGTATTTTTAGATTCATATGGGGAAAAAATTGGCGCGAAAATT
GTTGTTTTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCAGTGCAAGTAGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGATG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4981.37 Da        Isoelectric Point: 3.9150

>AT23468 WP_000237817.1 NC_011772:2290605-2290733 [Bacillus cereus G9842]
VVKDYDNDFFKEDNEDTTDFSLIKGDALQQVEELEEELKRKS

Download         Length: 129 bp

>AT23468 NC_011772:2290605-2290733 [Bacillus cereus G9842]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATGC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6D1SWF1

Antitoxin

Source ID Structure
AlphaFold DB B7IX39

References