Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3920447..3921279 Replicon chromosome
Accession NZ_CP091712
Organism Escherichia coli strain KFu014

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag L6L57_RS18730 Protein ID WP_000854753.1
Coordinates 3920905..3921279 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag L6L57_RS18725 Protein ID WP_001295723.1
Coordinates 3920447..3920815 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L57_RS18690 (3916280) 3916280..3916960 + 681 WP_001282919.1 WYL domain-containing protein -
L6L57_RS18695 (3917108) 3917108..3917785 + 678 WP_001097301.1 hypothetical protein -
L6L57_RS18700 (3917791) 3917791..3918024 + 234 WP_001278283.1 DUF905 family protein -
L6L57_RS18705 (3918114) 3918114..3918932 + 819 WP_001773857.1 DUF932 domain-containing protein -
L6L57_RS18710 (3919023) 3919023..3919508 + 486 WP_000214398.1 antirestriction protein -
L6L57_RS18715 (3919524) 3919524..3920000 + 477 WP_073544096.1 RadC family protein -
L6L57_RS18720 (3920063) 3920063..3920284 + 222 WP_000692311.1 DUF987 domain-containing protein -
L6L57_RS18725 (3920447) 3920447..3920815 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L6L57_RS18730 (3920905) 3920905..3921279 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
L6L57_RS18735 (3921276) 3921276..3921764 + 489 WP_000777545.1 DUF5983 family protein -
L6L57_RS18740 (3921776) 3921776..3921973 + 198 WP_000839281.1 DUF957 domain-containing protein -
L6L57_RS18745 (3922070) 3922070..3922639 + 570 WP_001290252.1 DUF4942 domain-containing protein -
L6L57_RS18750 (3922982) 3922982..3923152 + 171 Protein_3678 IS110 family transposase -
L6L57_RS18755 (3923963) 3923963..3924946 + 984 WP_024181915.1 KpsF/GutQ family sugar-phosphate isomerase -
L6L57_RS18760 (3925018) 3925018..3926166 + 1149 WP_000905931.1 capsule polysaccharide export inner-membrane protein KpsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T234678 WP_000854753.1 NZ_CP091712:3920905-3921279 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T234678 NZ_LR134031:188877-188984 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT234678 WP_001295723.1 NZ_CP091712:3920447-3920815 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT234678 NZ_LR134031:c188820-188763 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References