Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 6836..7337 | Replicon | plasmid pKGu016_3 |
| Accession | NZ_CP091707 | ||
| Organism | Escherichia coli strain KGu016 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | H1ZXU8 |
| Locus tag | L6L59_RS25745 | Protein ID | WP_000702247.1 |
| Coordinates | 6836..7096 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | L6L59_RS25750 | Protein ID | WP_001132407.1 |
| Coordinates | 7086..7337 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L6L59_RS25695 (L6L59_25695) | 2079..2240 | + | 162 | WP_001128311.1 | hypothetical protein | - |
| L6L59_RS25700 (L6L59_25700) | 2376..2528 | + | 153 | Protein_3 | DUF5431 family protein | - |
| L6L59_RS25705 (L6L59_25705) | 2473..2595 | + | 123 | WP_223202818.1 | Hok/Gef family protein | - |
| L6L59_RS25710 (L6L59_25710) | 2745..3341 | + | 597 | WP_000125164.1 | ProQ/FINO family protein | - |
| L6L59_RS25715 (L6L59_25715) | 3359..3643 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| L6L59_RS25720 (L6L59_25720) | 3717..4382 | - | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
| L6L59_RS25725 (L6L59_25725) | 4979..5308 | + | 330 | WP_000855119.1 | hypothetical protein | - |
| L6L59_RS25730 (L6L59_25730) | 5889..6212 | + | 324 | WP_000427403.1 | hypothetical protein | - |
| L6L59_RS25735 (L6L59_25735) | 6254..6463 | + | 210 | WP_000866036.1 | hypothetical protein | - |
| L6L59_RS25740 (L6L59_25740) | 6560..6784 | + | 225 | WP_000814381.1 | hypothetical protein | - |
| L6L59_RS25745 (L6L59_25745) | 6836..7096 | + | 261 | WP_000702247.1 | hypothetical protein | Toxin |
| L6L59_RS25750 (L6L59_25750) | 7086..7337 | + | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| L6L59_RS25755 (L6L59_25755) | 7887..8165 | + | 279 | WP_000545938.1 | hypothetical protein | - |
| L6L59_RS25760 (L6L59_25760) | 8553..8996 | - | 444 | WP_240755588.1 | hypothetical protein | - |
| L6L59_RS25765 (L6L59_25765) | 9293..9475 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| L6L59_RS25770 (L6L59_25770) | 9500..9937 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| L6L59_RS25775 (L6L59_25775) | 10068..10388 | - | 321 | WP_000206710.1 | hypothetical protein | - |
| L6L59_RS25780 (L6L59_25780) | 10392..10679 | - | 288 | WP_000212745.1 | hypothetical protein | - |
| L6L59_RS25785 (L6L59_25785) | 10681..11172 | - | 492 | WP_001167293.1 | hypothetical protein | - |
| L6L59_RS25790 (L6L59_25790) | 11505..11627 | - | 123 | Protein_21 | hypothetical protein | - |
| L6L59_RS25795 (L6L59_25795) | 11647..12246 | - | 600 | WP_182488076.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..58398 | 58398 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9817.29 Da Isoelectric Point: 10.0665
>T234657 WP_000702247.1 NZ_CP091707:6836-7096 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T234657 NZ_LR133996:2948553-2948771 [Shimwellia blattae]
ATGTCCGAAAAGCCACTAACTAAGACCGATTATTTAATGCGTCTGCGTCGCTGCCAGACAATTGACACCCTGGAACGCGT
TATTGAAAAGAATAAATATGAATTATCCGATACAGAGCTGGCGGTGTTTTACTCAGCAGCGGATCATCGCCTTGCAGAGC
TGACGATGAATAAACTTTATGACAAAATCCCATCATCTGTGTGGAAATTTGTCCGCTAA
ATGTCCGAAAAGCCACTAACTAAGACCGATTATTTAATGCGTCTGCGTCGCTGCCAGACAATTGACACCCTGGAACGCGT
TATTGAAAAGAATAAATATGAATTATCCGATACAGAGCTGGCGGTGTTTTACTCAGCAGCGGATCATCGCCTTGCAGAGC
TGACGATGAATAAACTTTATGACAAAATCCCATCATCTGTGTGGAAATTTGTCCGCTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT234657 WP_001132407.1 NZ_CP091707:7086-7337 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT234657 NZ_LR133996:2948148-2948528 [Shimwellia blattae]
ATGGACGAGTACTCACCAAAACGGCATGATATAGCGCAACTGCGTTTTCTTTGCGAAACTCTCTATCATGACTGTCTGGC
GAATCTTGGGGAAACTAACCGGGGTTGGGTTAATGATCCAACATCTGCCATAAACCTTCAGCTGAACGACTTAATTGAGC
ACATAGCGACTTTCGCACTTAATTATAAGATTAAGTATGATGATGACAGTAAATTAATTGAACAAATTGACGAGTATCTG
GACGATACCTTTACACTTTTCAGCAACTACGGCATTGATGCAAAAGATCTCCAGAAGTGGCAGAAGTCAGGAAATCGCCT
GTTCCGGTGCTTCGTCAACGCAAGCAGAGCTAACCCGGTTAGCCTCTCTCTCGAAAAATAA
ATGGACGAGTACTCACCAAAACGGCATGATATAGCGCAACTGCGTTTTCTTTGCGAAACTCTCTATCATGACTGTCTGGC
GAATCTTGGGGAAACTAACCGGGGTTGGGTTAATGATCCAACATCTGCCATAAACCTTCAGCTGAACGACTTAATTGAGC
ACATAGCGACTTTCGCACTTAATTATAAGATTAAGTATGATGATGACAGTAAATTAATTGAACAAATTGACGAGTATCTG
GACGATACCTTTACACTTTTCAGCAACTACGGCATTGATGCAAAAGATCTCCAGAAGTGGCAGAAGTCAGGAAATCGCCT
GTTCCGGTGCTTCGTCAACGCAAGCAGAGCTAACCCGGTTAGCCTCTCTCTCGAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|