Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4709439..4710364 Replicon chromosome
Accession NZ_CP091704
Organism Escherichia coli strain KGu016

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag L6L59_RS22710 Protein ID WP_014640052.1
Coordinates 4709439..4709825 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag L6L59_RS22715 Protein ID WP_024174200.1
Coordinates 4709855..4710364 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L59_RS22655 (4704946) 4704946..4705482 + 537 WP_021518223.1 5'-deoxynucleotidase -
L6L59_RS22660 (4705473) 4705473..4706351 + 879 WP_021518222.1 phosphoadenosine phosphosulfate reductase family protein -
L6L59_RS22665 (4706348) 4706348..4706551 + 204 WP_021518221.1 hypothetical protein -
L6L59_RS22670 (4706544) 4706544..4706783 + 240 WP_000476212.1 hypothetical protein -
L6L59_RS22675 (4706780) 4706780..4707334 + 555 WP_021518220.1 ead/Ea22-like family protein -
L6L59_RS22680 (4707336) 4707336..4707527 + 192 WP_001014291.1 hypothetical protein -
L6L59_RS22685 (4707530) 4707530..4707844 + 315 Protein_4454 DUF551 domain-containing protein -
L6L59_RS22690 (4708046) 4708046..4708288 + 243 Protein_4455 DUF551 domain-containing protein -
L6L59_RS22695 (4708288) 4708288..4708860 + 573 WP_001061345.1 3'-5' exonuclease -
L6L59_RS22700 (4708897) 4708897..4709178 + 282 WP_001093916.1 pyocin activator PrtN family protein -
L6L59_RS22705 (4709226) 4709226..4709399 - 174 WP_000390072.1 hypothetical protein -
L6L59_RS22710 (4709439) 4709439..4709825 - 387 WP_014640052.1 hypothetical protein Toxin
L6L59_RS22715 (4709855) 4709855..4710364 - 510 WP_024174200.1 Panacea domain-containing protein Antitoxin
L6L59_RS22720 (4710681) 4710681..4710785 - 105 Protein_4461 tRNA-dihydrouridine synthase -
L6L59_RS22725 (4711148) 4711148..4712110 - 963 WP_032180364.1 DUF2713 family protein -
L6L59_RS22730 (4712428) 4712428..4712943 + 516 WP_000416263.1 zinc uptake transcriptional repressor Zur -
L6L59_RS22735 (4712985) 4712985..4713194 - 210 WP_001030593.1 CsbD family protein -
L6L59_RS22740 (4713310) 4713310..4714635 - 1326 WP_001301116.1 MATE family efflux transporter DinF -
L6L59_RS22745 (4714708) 4714708..4715316 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4666282..4715316 49034


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T234644 WP_014640052.1 NZ_CP091704:c4709825-4709439 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T234644 NZ_LR133964:c4696651-4695734 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19559.39 Da        Isoelectric Point: 5.3338

>AT234644 WP_024174200.1 NZ_CP091704:c4710364-4709855 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp

>AT234644 NZ_LR133964:c4697415-4696657 [Klebsiella pneumoniae]
ATGGTAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References