Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4570672..4571507 Replicon chromosome
Accession NZ_CP091704
Organism Escherichia coli strain KGu016

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7U9IW37
Locus tag L6L59_RS21980 Protein ID WP_023356554.1
Coordinates 4571130..4571507 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A4Q0BE16
Locus tag L6L59_RS21975 Protein ID WP_032180374.1
Coordinates 4570672..4571040 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6L59_RS21940 (4566336) 4566336..4567016 + 681 WP_001282921.1 WYL domain-containing protein -
L6L59_RS21945 (4567164) 4567164..4567841 + 678 WP_001097302.1 hypothetical protein -
L6L59_RS21950 (4567847) 4567847..4568080 + 234 WP_001278293.1 DUF905 family protein -
L6L59_RS21955 (4568170) 4568170..4568988 + 819 WP_001175165.1 DUF932 domain-containing protein -
L6L59_RS21960 (4569254) 4569254..4569733 + 480 WP_000706978.1 antirestriction protein -
L6L59_RS21965 (4569749) 4569749..4570225 + 477 WP_001186774.1 RadC family protein -
L6L59_RS21970 (4570288) 4570288..4570509 + 222 WP_023356553.1 DUF987 domain-containing protein -
L6L59_RS21975 (4570672) 4570672..4571040 + 369 WP_032180374.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L6L59_RS21980 (4571130) 4571130..4571507 + 378 WP_023356554.1 TA system toxin CbtA family protein Toxin
L6L59_RS21985 (4571504) 4571504..4571653 + 150 Protein_4314 DUF5983 family protein -
L6L59_RS21990 (4571732) 4571732..4571926 + 195 WP_024181941.1 DUF957 domain-containing protein -
L6L59_RS21995 (4572011) 4572011..4572853 + 843 WP_022645115.1 DUF4942 domain-containing protein -
L6L59_RS22000 (4573602) 4573602..4575140 + 1539 WP_001187178.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4537163..4582953 45790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14052.01 Da        Isoelectric Point: 7.8045

>T234642 WP_023356554.1 NZ_CP091704:4571130-4571507 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFADERVIEQHIEAGIALCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T234642 NZ_LR133964:c4443079-4442546 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13633.36 Da        Isoelectric Point: 6.2058

>AT234642 WP_032180374.1 NZ_CP091704:4570672-4571040 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLELMLTSG
ELNHRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT234642 NZ_LR133964:c4443356-4443090 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9IW37

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q0BE16

References